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The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination

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Abstract

The melanocyte-stimulating hormone (MSH) receptor has a major function in the regulation of black (eumelanin) versus red (phaeomelanin) pigment synthesis within melanocytes. We report three alleles of the MSH-receptor gene found in cattle. A point mutation in the dominant allele E D gives black coat color, whereas a frameshift mutation, producing a prematurely terminated receptor, in homozygous e/e animals, produces red coat color. The wild-type allele E + produces a variety of colors, reflecting the possibilities for regulating the normal receptor. Microsatellite analysis, RFLP studies, and coat color information were used to localize the MSH-receptor to bovine Chromosome (Chr) 18.

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References

  • Ackland, J.F., Schwartz, N.B., Mayo, K.E., Dodson, R.E. (1992). Nonsteroidal signals originating in the gonads. Physiol. Rev. 72, 731–787.

    Google Scholar 

  • Adalsteinsson, S. (1970). Colour inheritance in Icelandic sheep and relation between colour, fertility and fertilization. J. Agric. Res. Icel. 2, 3–135.

    Google Scholar 

  • Adalsteinsson, S., Hersteinsson, P., Gunnarsson, E. (1987). Fox colors in relation to colors in mice and sheep. J. Hered. 78, 235–237.

    Google Scholar 

  • Adalsteinsson, S., Sponenberg, D.P., Alexieva, S., Russel, A.J.F. (1994). Inheritance of goat coat colors. J. Hered. 85, 267–272.

    Google Scholar 

  • Adalsteinsson, S., Bjarnadottir, S., Våge, D.I., Jonmundsson, J.V. (1995). Brown coat color in Icelandic cattle produced by the loci Extension and Agouti. J. Hered. 86, in press.

  • Becerril, C.M., Wilcox, C.J., Lawlor, T.J., Wiggans, G.R., Webb, D.W. (1993). Effects of percentage of white coat color on Holstein production and reproduction in a subtropical environment. J. Dairy Sci 76, 2286–2291.

    Google Scholar 

  • Bishop, M.D., Kappes, S.M., Keele, J.W., Stone, R.T., Sunden, S.L.F., Hawkins, G.A., Toldo, S.S., Fries, R., Grosz, M.D., Yoo, J., Beattie, C.W. (1994). A genetic linkage map for cattle. Genetics 136, 619–639.

    Google Scholar 

  • Bultman, S.J., Michaud, E.J., Woychik, R.P. (1992). Molecular characterization of the mouse agouti locus. Cell 71, 1195–1204.

    Google Scholar 

  • Chhajlani, V., Wikberg, J.E.S. (1992). Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA. FEBS Lett. 309, 417–420.

    Google Scholar 

  • Duhl, D.M.J., Vrieling, H., Miller, K.A., Wolff, G.L., Barsh, G.S. (1994). Neomorphic agouti mutations in obese yellow mice. Nature Genet. 8, 59–65.

    Google Scholar 

  • Gantz, I., Yamada, T., Tashiro, T., Konda, Y., Shimoto, Y., Miwa, H., Trent, J.M. (1994). Mapping of the gene encoding the melanocortin-1 (α-melanocyte stimulating hormone) receptor (MC1R) to human chromosome 16q24.3 by fluorescence in situ hybridization. Genomics 19, 394–395.

    Google Scholar 

  • Haldene, J.B.S., Smith, C.A.B. (1947). A new estimate of the linkage between the genes for colour-blindness and haemophilia in man. Ann. Eugen. 14, 10–31.

    Google Scholar 

  • Hearing, V.J., Tsukamoto, K. (1991). Enzymatic control of pigmentation in mammals. FASEB J. 5, 2902–2909.

    Google Scholar 

  • Jackson, I.J. (1993). Color-coded switches. Nature 362, 587–588.

    Google Scholar 

  • Jingami, H., Nakanishi, S., Imura, H., Numa, S. (1984). Tissue distribution of messenger RNAs coding for opioid peptide precursors and related RNA. Eur. J. Biochem. 142, 441–447.

    Google Scholar 

  • Lien, S., Rogne, S., Brovold, M.J., Alestrøm, P. (1990). A method for isolation of DNA from frozen (A.I.) bulls semen. J. Anim. Breed. Genet. 107, 74.

    Google Scholar 

  • Lu, D., Willard, D., Patel, I.R., Kadwell, S., Overton, L., Kost, T., Luther, M., Chen, W., Woychik, R.P., Wilkison, W.O., Cone, R.D. (1994). Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature 371, 799–802.

    Google Scholar 

  • Margioris, A.N., Liotta, A.S., Vaudry, H., Bardin, C.W., Krieger, D.T. (1983). Characterization of immunoreactive proopiomelanocortinrelated peptides in rat testes. Endocrinology 113, 663–671.

    Google Scholar 

  • Mercer, J.A., Seperack, P.K., Strobel, M.C., Copeland, N.G., Jenkins, N.A. (1991). Novel myosin heavy chain encoded by murine dilute coat colour locus. Nature 349, 709–713.

    Google Scholar 

  • Mountjoy, K.G., Robbins, L.S., Mortrud, M.T., Cone, R.D. (1992). The cloning of a family of genes that encode the melanocortin receptors. Science 257, 1248–1251.

    Google Scholar 

  • O'Brien, S.J., Womack, J.E., Lyons, L.A., Moore, K.J., Jenkins, N.A., Copeland, N.G. (1993). Anchored reference loci for comparative genome mapping in mammals. Nature Genet. 3, 103–112.

    Google Scholar 

  • Perry, W.L., Copeland, N.G., Jenkins, N.A. (1994). The molecular basis for dominant yellow agouti coat color mutations. Bioessays 16, 705–707.

    Google Scholar 

  • Robbins, L.S., Nadeau, J.H., Johnson, K.R., Kelly, M.A., Roselli-Rehfuss, L., Baack, E., Mountjoy, K.G., Cone, R.D. (1993). Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72, 827–834.

    Google Scholar 

  • Searle, A.G. (1968). Comparative Genetics of Coat Colour in Mammals. (London: Logos Press).

    Google Scholar 

  • Silvers, W.K. (1979). The agouti and extension series of alleles, umbrous, and sable. In The Coat Colors of Mice, A Model for Mammalian Gene Action and Interaction, W.K. Silvers, ed. (New York Springer-Verlag) pp. 6–44.

    Google Scholar 

  • Templeton, J.W., Stewart, A.P., Fletcher, W.S. (1977). Coat color genetics in the labrador retriever. J. Hered. 68, 134–136.

    Google Scholar 

  • Urabe, K., Aroca, P., Hearing, V.J. (1993). From gene to protein: determination of melanin synthesis. Pigm. Cell Res. 6, 186–192.

    Google Scholar 

  • Vaiman, D., Mercier, D., Moazami-Goudarzi, K., Eggen, A., Ciampolini, R., Lepingle, A., Velmala, R., Kaukinen, J., Varvio, S.L., Martin, P., Leveziel, H., Guerin, G. (1994). A set of 99 cattle microsatellites: characterization, synteni mapping, and polymorphism. Mamm. Genome 5, 288–297.

    Google Scholar 

  • Vanetti, M., Schönrock, C., Meyerhof, W., Höllt, V. (1994). Molecular cloning of a bovine MSH receptor which is highly expressed in the testis. FEBS Lett. 348, 268–272.

    Google Scholar 

  • Witte, O.N. (1990). Steel locus defines new multipotent growth factor. Cell 63, 5–6.

    Google Scholar 

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Klungland, H., Vage, D.I., Gomez-Raya, L. et al. The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination. Mammalian Genome 6, 636–639 (1995). https://doi.org/10.1007/BF00352371

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  • DOI: https://doi.org/10.1007/BF00352371

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