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Mapping of the Hmg1 gene and of seven related sequences in the mouse

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Abstract

The High Mobility Group 1 protein (HMG1) is an abundant and highly conserved chromosomal protein. Mouse HMG1 is encoded by the Hmg1 gene, containing four introns, but the murine genome contains many related sequences that are mostly retrotransposed pseudogenes. By using an interspecific cross, we have mapped the functional Hmg1 gene on mouse Chromosome (Chr) 5 and seven Hmg1-related sequences on Chrs 6, 8, 17, 18, and X.

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References

  • Agraway, M.G., Bowman, L.H. (1987). Transcriptional and translational regulation of ribosomal protein formation during mouse myoblast differentiation. J. Biol. Chem. 262, 4868–4875.

    Google Scholar 

  • Bianchi, M.E. (1994). Prokaryotic HU and eukaryotic HMG1: a kinked relationship. Mol. Microbiol. 14, 1–5.

    Google Scholar 

  • Bianchi, M.E., Beltrame, M., Falciola, L. (1992). The HMG box motif. In Nucleic Acids and Molecular Biology, F. Eckstein, D.M.J., Lilley, eds. (Berlin: Spring Verlag), Vol. 6, pp. 112–128.

    Google Scholar 

  • Bustin, M., Lehn, D.A., Landsman, D. (1990). Structural features of the HMG chromosomal proteins and their genes. Biochim. Biophys. Acta 1049, 231–243.

    Google Scholar 

  • Ceci, J.D. (1994). Mouse Chromosome 8. Mamm. Genome 5 (suppl.), S124-S138.

    Google Scholar 

  • Cheng, J., Mielnicki, L.M., Pruitt, S.C., Maquat, L.E. (1990). Nucleotide sequence of murine triosephosphate isomerase cDNA. Nucleic Acids Res. 18, 4261.

    Google Scholar 

  • Dietrich, W.F., Miller, J.C., Steen, R.G., Merchant, M., Damron, D., Nahf, R., Gross, A., Joyce, D.C., Wessel, M., Dredge, R.D., Marquis, A., Stein, L.D., Goodman, N., Page, D.C., Lander, E.S. (1994). A genetic map of the mouse with 4,006 simple sequence length polymorphisms. Nature Genet. 7, 220–245.

    Google Scholar 

  • Elliott, R.W., Moore, K.J. (1994). Mouse Chromosome 6. Mamm. Genome 5 (suppl.), S79-S103.

    Google Scholar 

  • Ferrari, S., Ronfani, L., Calogero, S., Bianchi, M.E. (1994). The mouse gene coding for high mobility group 1 protein (HMG1). J. Biol. Chem. 269, 28803–28808.

    Google Scholar 

  • Forejt, J., Artzt, K., Barlow, D.P., Hamvas, R.M.J., Lindahl, K.F., Lyon, M.F., Klein, J., Silver, L.M. (1994). Mouse Chromosome 17. Mamm. Genome 5 (suppl.), S238-S258.

    Google Scholar 

  • Gariboldi, M., Manenti, G., Canzian, F., Falvella, F.S., Radice, M.T., Pierotti, M.A., Della Porta, G., Binelli, G., Dragani, T.A. (1993). A major susceptibility locus to murine lung carcinogenesis maps on chromosome 6. Nature Genet. 3, 132–136.

    Google Scholar 

  • Herman, G.E., Bloyd, Y., Chapman, V., Chatterjee, A., Brown, S.D.M. (1994). Mouse X Chromosome, Mamm. Genome 5 (suppl.), S276-S288.

    Google Scholar 

  • Jeffreys, A.J., Wilson, V., Kelly, R., Taylor, B.A., Bulfield, G. (1982). “Mouse DNA Fingerprints”: analysis of chromosome localization and germ line stability of hypervariable loci in recombinant inbred strains. Nucleic Acids Res. 15, 2823–2836.

    Google Scholar 

  • Johnson, K.R., Davisson, M.T. (1994). Mouse Chromosome 18. Mamm. Genome 5 (suppl.), S259-S265.

    Google Scholar 

  • Kozak, C.A., Goffinet, A., Stephenson, D.A. (1994). Mouse Chromosome 5. Mamm. Genome 5 (Suppl.), S65-S78.

    Google Scholar 

  • Lander, E.S., Green, P., Abrahamson, J., Barlow, A., Daly, M., Lincoln, S.E., Newburg, L. (1987). MAPMAKER: an interactive computer package for constructing primary genetics maps of experimental and natural populations. Genomics 1, 174–181.

    Google Scholar 

  • Lilley, D.M.J. (1992). HMG has DNA wrapped up. Nature 357, 282–283.

    Google Scholar 

  • Lincoln, S.E., Daly, M., Lander, E.S. (1992). Constructing Genetic Maps with MAPMAKER/EXP 3.0. Whitehead Institute Technical Report, 3rd edition.

  • Manenti, G., Binelli, G., Gariboldi, M., Canzian, F., De Gregorio, L., Falvella, F.S., Dragani, T.A., Pierotti, M.A. (1994). Multiple loci affect genetic predisposition to hepatocarcinogenesis in mice. Genomics 23, 118–124.

    Google Scholar 

  • McConlogue, L., Gupta, M., Wu, L., Coffino, P. (1984). Molecular cloning and expression of the mouse ornithine decarboxylase gene. Proc. Natl. Acad. Sci. USA 81, 540–544.

    Google Scholar 

  • Nakamichi, N., Rhoads, D.D., Roufa, D.J. (1983). The Chinese hamster cell hemetine resistance gene: analysis of cDNA and genomic sequences encoding ribosomal protein S14. J. Biol. Chem. 258, 13236–13242.

    Google Scholar 

  • Onate, S.A., Prendergast, P., Wagner, J.P., Nissen, M., Reeves, R., Pettijohn, D.E., Edwards, D.P. (1994). The DNA bending protein HMG-1 enhances progesterone receptor binding to its target DNA sequences. Mol. Cell. Biol. 14, 3376–3391.

    Google Scholar 

  • Pauken, C.M., Nagle, D.L., Bucan, M., Lo, C.W. (1994). Molecular cloning, expression analysis, and chromosome localization of mouse Hmg1-containing sequences. Mamm. Genome 5, 91–99.

    Google Scholar 

  • Pilon, A.L., Kozak, C.A., Nebert, D.W., Puga, A. (1993). Localization of the murine Hmg1 gene, encoding an HMG-box protein, to mouse chromosome 2. Mamm. Genome 4, 612–614.

    Google Scholar 

  • Shirakata, M., Huppi, K., Usuda, S., Okazaki, K., Yoshida, K., Sakano, H. (1991). HMG1-related DNA-binding protein isolated with V-(D)-J recombination signal probes. Mol. Cell. Biol. 11, 4528–4536.

    Google Scholar 

  • Shirakawa, H., Yoshida, M. (1992). Structure of a gene coding for human HMG2 protein. J. Biol. Chem. 267, 6641–6645.

    Google Scholar 

  • Yotov, W.V., St-Arnaud, R. (1992). Nucleotide sequence of a mouse cDNA encoding the non-histone chromosomal high mobility group protein-1 (HMG1). Nucleic Acids Res. 20, 3516.

    Google Scholar 

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Gariboldi, M., De Gregorio, L., Ferrari, S. et al. Mapping of the Hmg1 gene and of seven related sequences in the mouse. Mammalian Genome 6, 581–585 (1995). https://doi.org/10.1007/BF00352361

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  • DOI: https://doi.org/10.1007/BF00352361

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