Abstract
We have sequenced the mitochondrial-encoded NADH dehydrogenase subunit 6 gene from 19 species of birds. Comparison of the derived amino-acid sequences in 22 avian species, six mammals, and two fishes, reveals an intragenic rearrangement in mammals. The C-terminal half of the mammalian protein includes an internal insertion of 10–15 amino acids and a C-terminal deletion of 8–9 amino acids. Based on comparative sequence alignments and hydropathy profile analysis, five hydrophobic segments (designated I to V) corresponding to transmembrane regions are proposed. In this structural model of NADH dehydrogenase subunit 6, the mammalian insertion is found in a variable loop region between transmembrane segments IV and V.
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Communicated by K. Wolf
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Moum, T., Willassen, N.P. & Johansen, S. Intragenic rearrangements in the mitochondrial NADH dehydrogenase subunit 6 gene of vertebrates. Curr Genet 25, 554–557 (1994). https://doi.org/10.1007/BF00351677
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DOI: https://doi.org/10.1007/BF00351677