Abstract
A human hair cuticle ultrahigh-sulphur keratin (UHSK) gene (KRN1) has been mapped by Southern analysis of a somatic cell hybrid panel and by in situ hybridization. A probe containing the coding region of this gene mapped to 11pter->11q21 using the hybrid cell panel and on in situ hybridization mapped to two regions on chromosome 11: the distal part of 11p15, most likely 11p15.5, and the distal part of 11q13, most likely 11q13.5. A probe from the 3′ non-coding region of KRN1 mapped to 11q13.5 indicating that this was the map location of the cloned gene. The sequence of 11p15.5 is termed KRN1-like (KRN1L). The results reveal that the cuticle UHSK gene family is clustered in the human genome.
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Present address: The Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3, 9DU, United Kingdom.
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MacKinnon, P.J., Powell, B.C., Rogers, G.E. et al. An ultrahigh-sulphur keratin gene of the human hair cuticle is located at 11q13 and cross-hybridizes with sequences at 11p15. Mammalian Genome 1, 53–56 (1991). https://doi.org/10.1007/BF00350846
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DOI: https://doi.org/10.1007/BF00350846