Abstract
The mouse t complex responder locus (Tcr) is centrally involved in the phenomenon of male-specific transmission ratio distortion (TRD) through its action in haploid germ cells. Previously, we identified a candidate gene, Tcp-10b, whose t allele generates alternatively spliced transcripts. The full-length Tcp-10b t transcript is present in pre- and postmeiotic germ cells and encodes a product that is virtually identical with that encoded by the wild-type allele. The alternatively spliced t-specific transcript is observed in postmeiotic haploid spermatids and would encode an altered polypeptide that could convey the Tcr t phenotype. To assess their function, we have introduced constructs representing each Tcp-10b t transcript into transgenic mice. Breeding experiments demonstrate that these two constructs alter the transmission ratios of t haplotypes from male mice, but in opposite directions. The results provide support for the hypothesis that Tcp-10b t is a component of the Tcr locus.
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Snyder, L.C., Silver, L.M. Distortion of transmission ratio by a candidate t complex responder locus transgene. Mammalian Genome 3, 588–596 (1992). https://doi.org/10.1007/BF00350626
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DOI: https://doi.org/10.1007/BF00350626