Abstract
The effects on pancreatic islet allograft survival of donor-specific blood transfusions (DST) in combination with pre- and posttransplant immunosuppression were studied. A total of 12 groups of rats (n=105) with chemically induced diabetes underwent islet allotransplantation. Multiple DST or third-party blood transfusions (TPT) were given prior to transplantation. Pretransplant immunosuppression consisted of azathioprine and prednisolone, and low-dose cyclosporin A was used for posttransplant immunosuppression. TPT, as well as separate or combined pre- and posttransplant immunosuppression without blood transfusions, did not prolong islet allograft survival. DST resulted in either primary nonfunction of the islet allografts or a markedly decreased islet allograft survival. These findings contrast with the beneficial effect of DST on whole-organ allograft survival in rats previously described by others.
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van der Vliet, J.A., van der Hem, L.G., Field, M.J. et al. Failure to prolong pancreatic islet allograft survival in rats with donor-specific blood transfusions and immunosuppression. Transplant Int 1, 146–148 (1988). https://doi.org/10.1007/BF00348837
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DOI: https://doi.org/10.1007/BF00348837