Abstract
Breast conservation surgery and radiation therapy are chosen with increasing frequency in breast cancer management. In addition to the risk of developing a contralateral malignancy, these women are at risk for local recurrence or a new primary lesion in the conserved breast. Most of these ipsilateral recurrences can be treated successfully with salvage mastectomy. The prognosis with salvage mastectomy depends on several factors, including the method of diagnosis of the recurrent tumor, the size of the recurrence, the extent of breast involvement at recurrence, the time interval from initial surgery to recurrence, the involvement of axillary nodes at the initial diagnosis and at the time of recurrence, and the histopathology of the recurrent tumor.
Résumé
On préconise de plus en plus souvent une chirugie conservatrice associée à la radiothérapie en matière de cancer du sein. En plus du risque de développer un cancer de l'autre côté, ces femmes sont à risque de récidive locale ou de faire un deuxième cancer dans le sein conservé. La plupart de ces récidives, cependant, peuvent être traitées convenablement par une mastectomie de sauvetage. En revanche, le pronostic de ces mastectomies de sauvetage dépend de plusieurs facteurs, y compris la méthode du diagnostic de la récidive, la taille de la récidive, l'étendue de la lésion au moment de la récidive, l'intervalle entre la chirurgie initiale et la récidive ainsi que l'histologie de la récidive.
Resumen
La cirugía conservadora del seno y la radioterapia son las modalidades terapéuticas que hoy se escogen con creciente frecuencia para el manejo del cáncer mamario. Además del peligro de contraer una neoplasia contralateral, las mujeres que padecen la enfermedad poseen el riesgo de recurrencia local o de la aparición de un nuevo cáncer primario en el seno que ha sido conservado. La mayoría de estas recurrencias ipsilaterales pueden ser exitosamente tratadas con mastectomía de salvamento.
El pronóstico con la mastectomía de salvamento depende de diversos factores, que incluyen el método de diagnóstico del tumor recurrente, el tamaño de la lesión recurrente, la extensión afectada del seno en el momento de la recurrencia y el intervalo entre la cirugía inicial y la recurrencia, el estado de invasión axilar en el momento del diagnóstico inicial y en el de la recurrencia y la histopatología del tumor recurrente.
Similar content being viewed by others
References
Fisher, B., Redmond, C., Poisson, R., et al.: Eight year results of a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer. N. Engl. J. Med. 320:822, 1989
Osborne, M.: Salvage mastectomy. Semin. Surg. Oncol. 7:291, 1991
Osborne, M.P., Ormiston, N., Harmer, C.L., McKinna, J.A., Baker, J., Greening, W.P.: Breast conservation in the treatment of early breast cancer: a 20-year follow-up. Cancer 53:349, 1984
Stotter, A., McNeese, M., Ames, F., Oswald, M., Ellerbroek, N.: Predicting the rate and extent of locoregional failure after breast conservation therapy for early breast cancer. Cancer 64:2217, 1989
Harris, J., Recht, A., Amalric, R., et al.: Time course and prognosis of local recurrence following primary radiation therapy for early breast cancer. J. Clin. Oncol. 2:37, 1984
Fourquet, A., Campana, F., Zafrani, B., et al.: Prognostic factors of breast recurrence in the conservative management of early breast cancer: a 25-year follow-up. Int. J. Radiat. Oncol. Biol. Phys. 17:719, 1989
Haffty, B., Goldberg, N., Fischer, K., et al.: Conservative surgery and radiation therapy in breast carcinoma: local recurrence and prognostic implications. Int. J. Radiat. Oncol. Biol. Phys. 17:727, 1989
Recht, A., Schnitt, S., Connolly, J., et al.: Prognosis following local or regional recurrence after conservative surgery and radiotherapy for early stage breast carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 16:3, 1989
Fowble, B., Solin, L.J., Schultz, D.J., Rubenstein, J., Goodman, R.L.: Breast recurrence following conservative surgery and radiation: patterns of failure, prognosis and pathologic findings from mastectomy specimens with implications for treatment. Int. J. Radiat. Oncol. Biol. Phys. 19:833, 1990
Chauvet, B., Reynaud-Bougnous, A., Calais, G., et al.: Prognostic significance of breast relapse after conservative treatment in nodenegative early breast cancer. Int. J. Radiat. Oncol. Biol. Phys. 19:1125, 1990
Barr, L., Brunt, A., Phillips, R., Ellis, H.: Salvage mastectomy after failed breast conserving therapy for carcinoma of the breast. Ann. R. Coll. Surg. Engl. 73:126, 1991
Leung, S., Otmezguine, Y., Calitchi, E., Mazeron, J.J., Le Bourgeois, J.P., Pierquin, B.: Locoregional recurrences following radical external beam irradiation and interstitial implantation for operable breast cancer—a twenty three year experience. Radiother. Oncol. 5:1, 1986
Cajucom, C., Tsangaris, T., Nemoto, T., Driscoll, D., Penetrante, R., Holyoke, E.: Results of salvage mastectomy for local recurrence after breast conserving surgery without radiation therapy. Cancer 71:1774, 1993
Dershaw, D., McCormick, B., Cox, L., Osborne, M.: Differentiation of benign and malignant local tumor recurrence after lumpectomy. A.J.R. Am. J. Roentgenol. 155:35, 1990
Kurtz, J., Amalric, R., Brandone, H., et al.: Local recurrence after breast conserving surgery and radiotherapy. Cancer 63:1912, 1989
Abner, A., Recht, A., Eberlein, T., et al.: Prognosis following salvage mastectomy for recurrence in the breast after conservative surgery and radiation therapy for early stage breast cancer. J. Clin. Oncol. 11:44, 1993
Dershaw, D., McCormick, B., Osborne, M.: Detection of local recurrence after conservative therapy for breast carcinoma. Cancer 70:493, 1992
Kurtz, J., Spitalier, J., Amalric, R., et al.: The prognostic significance of late local recurrence after breast-conserving therapy. Int. J. Radiat. Oncol. Biol. Phys. 18:87, 1990
Osborne, M., Borgen, P., Wong, G., Rosen, P., McCormick, B.: Salvage mastectomy for local and regional recurrence after breast-conserving operation and radiation therapy. Surg. Gynecol. Obstet. 174:189, 1992
Osborne, M.P., Borgen, P.I., Wong, G.Y., Rosen, P.P., McCormick, B.: Salvage mastectomy for local-regional relapse after breast conserving surgery and radiation therapy. Proc. Am. Radium Soc. 53:21, 1991
Osborne, M., Borgen, P.: Role of mastectomy in breast cancer. Surg. Clin. North Am. 70:1023, 1990
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Osborne, M.P., Simmons, R.M. Salvage surgery for recurrence after breast conservation. World J. Surg. 18, 93–97 (1994). https://doi.org/10.1007/BF00348198
Issue Date:
DOI: https://doi.org/10.1007/BF00348198