Skip to main content

Advertisement

SpringerLink
Log in

The bone marrow scan in experimental osteomyelitis

  • Articles
  • Published:
Skeletal Radiology Aims and scope Submit manuscript

Abstract

Osteomyelitis causes an inflammatory reaction within the bone marrow early in its course, suggesting that bone marrow imaging with Tc-sulfurcolloid could be used for early detection of the disease. To test this hypothesis, 11 rabbits were inoculated with Staphylococcus aureus, 7 adults in the bone marrow and 4 immature rabbits in the epiphyseal plate. Six rabbits developed osteomyelitis by radiographic and pathologic criteria. Each demonstrated a marked decrease in reticuloendothelial function in the area of osteomyelitis, 4–11 days before radiographic changes were noted. The bone marrow scan was normal in septic arthritis, which was present in some animals before osteomyelitis became evident. These findings suggest that the bone marrow scan is a potentially useful study in early detection of osteomyelitis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Alavi, A., Bond, J.P, Kuhl, D.E., Creech, R.H.: Scan detection of bone marrow infarcts in sickle cell disorders. J. Nucl. Ned. 15, 1003 (1974)

    Google Scholar 

  2. DeNardo, S.J., Hammel, C.F., Lewis, J.P., DeNardo, G.F.: Assessment of bone marrow in sickle disease (Abstract). J. Nucl. Med. 13, 425 (1972)

    Google Scholar 

  3. Duszynski, D.O., Kohn, J.P., Afshani, E., Riddlesberger, M.M., Jr.: Early radionuclide diagnosis of acute osteomyelitis. Radiology 117, 337 (1975)

    Google Scholar 

  4. Gilday, D.L., Paul, D.J., Paterson, J.: Diagnosis of osteomyelitis in children by combined blood pool and bone imaging Radiology 117, 331 (1975)

    Google Scholar 

  5. Robbins, S.F.: Pathological Basis of Disease, p. 1437. Philadelphia: W.B. Saunders 1974

    Google Scholar 

  6. Snapper, I.: Bone Diseases in Medical Practice, p. 12, New York: Grune & Stratton 1957

    Google Scholar 

  7. Waldvogel, F.A., Medoff, G., Swartz, M.N.: Osteomyelitis, p. 4. Springfield, Ill.: Charles C Thomas 1971

    Google Scholar 

Download references

Author information

Author notes

  1. A. E. James Jr. M.D.

    Present address: Department of Radiology, Vanderbilt University Hospital, 37203, Nashville, TN, U.S.A.

Authors and Affiliations

  1. Department of Radiologic Pathology, Armed Forces Institute of Pathology, 20306, Washington D.C., U.S.A.

    D. S. Feigin M.D., H. W. Strauss M.D. & A. E. James Jr. M.D.

Authors
  1. D. S. Feigin M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. W. Strauss M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. E. James Jr. M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by grant UFPHF GM 10548 NIH, Bethesda, Md.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Feigin, D.S., Strauss, H.W. & James, A.E. The bone marrow scan in experimental osteomyelitis. Skeletal Radiol. 1, 103–108 (1976). https://doi.org/10.1007/BF00347415

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00347415

Key words

Search

Navigation