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Neonatal and infantile candidal arthritis with or without osteomyelitis: A clinical and radiographical review of 21 cases

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Abstract

Four cases of candidal arthritis and osteomyelitis are presented and 17 others are reviewed from the literature. The clinical and radiographic aspects of the entity are discussed in detail and compared with those of bacterial septic arthritis. The role of predisposing factors are elaborated. An increase in the incidence of the disease is anticipated and the diagnostic difficulties are enumerated.

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References

  1. Alder, S., Randall, J., Plotkin, S.A.: Candidal osteomyelitis and arthritis in a neonate. Am. J. Dis. Child 123, 595 (1972)

    Google Scholar 

  2. Curry, C.R., Quic, P.G.: Fungal septicemia in patients receiving parenteral hyperalimentation. N. Engl. J. Med. 285, 1221 (1971)

    Google Scholar 

  3. Fitzgerald, E., Shell, J.L., Gordon, S.L.: Candida arthritis. Clin. Orthop. 106, 143 (1975)

    Google Scholar 

  4. Freeman, J.B., Wienke, J.W., Soper, R.T.: Candida osteomyelitis associated with intravenous alimentation. J. Pediatr. Surg. 9, 783 (1974)

    Google Scholar 

  5. Greenman, R., Becker, J., Campbell, G., Remington, J.: Coccidoidal synovitis of the knee. Arch. Intern. Med. 135, 526 (1975)

    Google Scholar 

  6. Hart, P.D., Russell, E., Jr., Remington, J.S.: The Compromised host and infection. II. Deep fungal infection. J. Infect. Dis. 120, 169 (1969)

    Google Scholar 

  7. Heberling, J.A.: A review of two hundred and one cases of suppurative arthritis. J. Bone Joint Surg. [Am.]. 23, 917 (1941)

    Google Scholar 

  8. Hill, H.R., Mitchell, T.G., Matsen, J.M., Quic, P.G.: Recovery from disseminated candidiasis in a premature neonate. Pediatrics 53:5, 748 (1974)

    Google Scholar 

  9. Hollingworth, J.W., Carr, J.: Experimental candidal arthritis in the Rabbit. Sabouraudia 2, 56 (1973)

    Google Scholar 

  10. Huppert, M., Cazin, J., Jr.: Pathogenesis of Candida albicans infection following antibiotic therapy, II. Further studies of the effect of antibiotics on the in vitro growth of Candida albicans. J. Bacteriol. 70, 435 (1955)

    Google Scholar 

  11. Keller, M.A., Sellers, B.B., Melish, M.E., Kaplan, G.W., Miller, K.E., Mendoza, S.A.: Systemic candidiasis in infants. Am. J. Dis. Child. 131, 1260 (1977)

    Google Scholar 

  12. Klein, J.D., Yamauchi, T., Horlick, S.P.: Neonatal candidiasis, meningitis and arthritis: Observations and a review of the literature. J. Pediatr. 81, 31 (1972)

    Google Scholar 

  13. Lachman, R.S., Yamauchi, T., Klein, J.D.: Neonatal systemic candidiasis and arthritis. Radiology 105, 631 (1972)

    Google Scholar 

  14. Lauria, D.B., Browne, H.G.: The effects of cortisone on experimental fungus infections. Ann. NY Acad. Sci. 89, 39 (1960)

    Google Scholar 

  15. Lertratanakul, Y., Glassford, G.H., Rubinstein, H.M.: Arthritis and osteomyelitis due to Candida albicans: A case report. J. Rheumatol. 4, 317 (1977)

    Google Scholar 

  16. Liberti, J.H., Hughes, R.A.: Another case of disseminated candidiasis. Pediatrics 55, 897 (1975)

    Google Scholar 

  17. Murray, H.W., Fialk, M.A., Roberts, R.B.: Candida arthritis: A manifestation of disseminated candidiasis. Am. J. Med. 60, 587 (1976)

    Google Scholar 

  18. Mazumda, P.K., Marks, M.I.: Candida albicans infections in hospitalized children. Clin. Pediatr. 14, 123 (1975)

    Google Scholar 

  19. Nelson, J.D., Koontz, W.C.: Septic arthritis in infants and children: A review of 117 cases. Pediatr. 38, 951 (1966)

    Google Scholar 

  20. Nelson, J.D.: Follow up: The bacterial etiology and antibiotic management of septic arthritis in infants and children. Pediatr. 50, 440 (1970)

    Google Scholar 

  21. Nickerson, W.J., Mankowski, Z.A.: Polysaccharide medium of known composition favoring Chlamydospore formation in Candida albicans. J. Infect. Dis. 92, 20 (1953)

    Google Scholar 

  22. Noble, H.B., Lyne, E.D.: Candida osteomyelitis and arthritis from hyperalimentation therapy. J. Bone Joint Surg. [Am.] 56, 825 (1974)

    Google Scholar 

  23. Pittard, W.B., Thullen, J.D., Fanaroff, A.A.: Neonatal septic arthritis. J. Pediatr. 88, 621 (1976)

    Google Scholar 

  24. Pruitt, A.W., Achord, J.L., Fales, F.W., Patterson, J.H.: Glucose-galactose malabsorption complicated by Monilia arthritis. Pediatr. 43, 106 (1969)

    Google Scholar 

  25. Reiser, V.M., Rupp, N., Farber, D.: Röntgenologische Befunde bei der septischen Candida-Arthritis. Fortschr. Röntgenstr. 129, 335 (1978)

    Google Scholar 

  26. Sheldon, W.H., Bauer, H.: The role of predisposing factors in experimental fungus infections. J. Lab. Invest. 11, 1184 (1962)

    Google Scholar 

  27. Vialatte, J., Meyer, B., Cotlenko, Mme., Raverdy, Mme., Drouet, E.: Arthrite suppurée de genou à Candida albicans chez un nourrisson au cours d'une moniliase généralisée. Guerison. Arch. Fr. Pediatr. 17, 1214 (1960)

    Google Scholar 

  28. Wiley, E.L., Hutchins, G.M.: Superior vena cava syndrome secondary to Candida thrombophlebitis complicating parenteral almentation. J. Pediatr. 91, 977 (1977)

    Google Scholar 

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Yousefzadeh, D.K., Jackson, J.H. Neonatal and infantile candidal arthritis with or without osteomyelitis: A clinical and radiographical review of 21 cases. Skeletal Radiol. 5, 77–90 (1980). https://doi.org/10.1007/BF00347327

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