Skeletal Radiology

, Volume 1, Issue 3, pp 145–160 | Cite as

Primary malignant fibrous histiocytoma (fibrous xanthoma) of bone

  • Frieda Feldman
  • Raffaele Lattes


The probable histiocytic origin of a group of benign and malignant tumors known as histiocytomas or fibrous xanthomas appears to be well established and is based on a combination of conventional light microscopy, tissue culture and ultrastructural studies. Our experience with 23 cases of primary malignant fibrous histiocytoma of bone is presented, together with a review of additional cases documented in the literature. Particular emphasis has been placed on the radiologic aspects of primary malignant fibrous histiocytoma of bone, together with a brief review of its clinical and histologic features. The fact that the skeleton can be involved de novo rather than by direct extension from neighboring soft tissue tumors or by metastatic spread is a relatively new concept.

Key words

Bone neoplasm Reticuloendothelial system Neoplasm Fibrous xanthoma, malignant Histiocytoma, malignant Primary malignant fibrous histiocytoma 


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Copyright information

© International Skeletal Society 1977

Authors and Affiliations

  • Frieda Feldman
    • 1
  • Raffaele Lattes
    • 1
  1. 1.Department of Radiology, College of Physicians and SurgeonsColumbia-Presbyterian Medical CenterNew YorkUSA

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