Skip to main content
Log in

Intracranial arterial aneurysm complicating Behçet's disease

  • Case Reports
  • Published:
Neurosurgical Review Aims and scope Submit manuscript

Abstract

Behçet's disease, a rare condition in central Europe but more common in Turkey where it was originally described, is characterized clinically by the presence of a diagnostic triad of oral and genital aphthous ulcers, meningitis, and relapsing iridocyclitis. Vascularlesions including arterial and venous occlusions, arterial aneurysms and varices are one of the common complications of Behçet's disease occur most commonly in the abdominal aorta, femoral arteries and pulmonary arteries. There have been only four reports of aneurysms of cerebral arteries in the literature. The authors describe a patient with Behçet's disease who suffered secondary subarachnoid hemorrhage due to a ruptured aneurysm of the anterior communicating artery 3 years after the initial diagnosis. This case report draws further attention to this rare entity in patients with Behçet's disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Akoglu T, E Akoglu, H Kozakoglu, C Turgan, T Firat, S Caglar: Immunocomplexes in Behçet's disease. Studies in joint Disease. A interdisciplinary symposium. Bone and Joint Research Unit. The London Hospital, London, 1978

    Google Scholar 

  2. Altinörs N, E Senveli, N Arda, A Turker, Z Kars, N Cinar, S Özkan: Intracerebral hemorrhage and hematoma in Behçet's disease. Case Report. Neurosurgery 21 (1987) 582–583

    Google Scholar 

  3. Behçet H: Über rezidiverende Aphthöse, durch ein Virus verursachte Geschwüre am Mund, am Auge und den Genitalien. Dermatol Monatsschr 105 (1937) 1152–1157

    Google Scholar 

  4. Buge A, D Vincent, G Rancurel, H Dechy, M Dorra, C Betourne: Behçet's diseases with multiple intracranial arterial aneurysms. Rev Neurol (Paris) 143 (1987) 832–835

    Google Scholar 

  5. Chajek T, M Fainaru: Behçet's disease. Report of 41 cases and a review of the literature. Medicine 54 (1975) 179–196

    Google Scholar 

  6. Colvard DM, DM Robertson, JD O'Duffy. The ocular manifestations of Behçet's disease. Arch Ophthalmol 95 (1977) 1813–1817

    Google Scholar 

  7. Donatsky O: An immunofluorescence study on the cross-reaction between strep 2A and human oral mucosa. Scand J Dent Res 83 (1975) 111–119

    Google Scholar 

  8. Erken E, T Akoglu, H Kozakoglu: Serum amyloid A protein in Behçet's disease (abstract). 6th International Congress on Immunology Toronto, 420, 1986

  9. Evans AD, CA Pallis, JD Spillane: Involvement of nervous system in Behçet's syndrome. Lancet 2 (1957) 349–352

    Google Scholar 

  10. Hamza M: Large artery involvement in Behçet's disease. Semin Arthritis Rheum 8 (1979) 223–260

    Google Scholar 

  11. Hoover CI, JS Greenspan: Immunochemical comparison of cell-wall antigens of various viridans streptococci including strain 2 A2+3 HOT from recurrent oral aphtous ulceration in man. Arch Oral Biol 28 (1983) 917–922

    Google Scholar 

  12. Jenkins AM, AIS Macpherson, B Nolan, E Housley: Peripheral aneurysms in Behçet's disease. Br J Surg 63 (1976) 199–202

    Google Scholar 

  13. Kaneko F, Y Takahashi, Y Muramatsu, Y Miura: Immunological studies on aphthous ulcer and erythema nodosum-like eruptions in Behçet's disease. Br J Dermatol 113 (1985) 303–312

    Google Scholar 

  14. Katoh K, K Matsunaga, Y Ishigatsubo, J Chiba, K Tani, H Kitamura, S Tani, BS Handwerger: Pathologically defined Neuro-vasculo-entero-Behçet's disease. J Rheumatol 12 (1985) 1186–1190

    Google Scholar 

  15. Kerr JS, ES Roac, SH Sinal, JM Mc Whorter: Intracranial arterial aneurysms complicating Behçet's disease. J Child Neurol 4 (1989) 147–149

    Google Scholar 

  16. Lehner T: Immuno-pathology of Behçet's syndrome. In: Lehner T, CG Barnes, (eds): Behçet's Syndrome London: Academic Press 1979

    Google Scholar 

  17. Martin DM, DC Nelm, BF Mackler, DL Peavy: Lymphoproliferative responses induced by streptococcal antigens in recurrent aphtous stomatitis and Behçet's syndrome. Clin Immunol Immunopathol 13 (1979) 146–155

    Google Scholar 

  18. Matsumoto T, T Uakusa, Y Fukuda: Vasculo-Behçet's disease. A Pathologic Study of Eight Cases. Human Pathol 22 (1991) 45–51

    Google Scholar 

  19. Mizushima Y: Chemotaxis and phagocytosis of leukocytes in Behçet's disease: an overview. In: Lehner T, Barnes CG (eds): Recent advences in Behçet's disease. Roayal Soviety of Medicine Services, 1986

  20. Mizushima Y, T Matsuda, K Hoshi, S Ohno: Induction of Behçet's disease symptoms following dental treatment and streptococcal antigen skin test. J Rheumatol 15 (1988) 1029–1030

    Google Scholar 

  21. Mortada A, IZE Iman: Virus etiology of Behçet's syndrome. Brit J Ophtal 48 (1964) 250–254

    Google Scholar 

  22. Nagata K: Recurrent intracranial hemorrhage in Behçet's disease. J Neurol Neurosurg Psychiatry 48 (1985) 190–192

    Google Scholar 

  23. Ohno S: Clinical and immunological studies on ocular lesions en Behçet's Disease. In: Inaba G (ed.): Behçet's disease Tokyo: University of Tokyo Press 1981

    Google Scholar 

  24. Ohno S: Behçet's disease in the world. In: Lehner T, CG Barnes (eds). Recent advances in Behçet's disease. Royal Society of Medicine Services 1986

  25. Oshima Y, T Shimuzu, R Yokohari, T Matsumoto, K Kano, T Kagami, H Nagaya: Clinical studies on Behçet's syndrome. Ann Rheum Dis 22 (1963) 36–39

    Google Scholar 

  26. Pamir MN, T Kansu, A Erbengi, T Zileli: Pailledema in Behçet's syndrome. Arch Neurol 38 (1981) 643–645

    Google Scholar 

  27. Park JH, MC Han, MA Bettmann: Arterial manifestation of Behçet's disease. AJR 143 (1984) 821–825

    Google Scholar 

  28. Rubinstein LJ, H Ulrich: Meningoencephalitis of Behçet's disease. Brain 86 (1963) 151–160

    Google Scholar 

  29. Sakane T, N Suzuki, Y Ueda, S Takade, Y Murakawa, T Hoshino, Y Niwa, T Tsunematsu. Analysis of interleukin 2 activity in patients with Behçet's — disease: ability of T cells to procedure and respond to interleukin-2. Arthritis Rheum 29 (1986) 371–378

    Google Scholar 

  30. Shimizu T: Clinicopathological studies on Behçet's disease. In: Dilsen N, M Konice, C Ovul (eds): Behçet's disease: Proceedings of an International Symposium on Behçet's disease. Excerpta Medica Amsterdam-Oxford 1979

    Google Scholar 

  31. Shimizu T, GE Ehrlich, G Inaba, K Hayaski: Behçet's disease. Semin Arthritis Rheum 8 (1979) 223–260

    Google Scholar 

  32. Shimizu T, T Ogino: Clinico-pathological studies on the intestinal lesions in Behçet's disease with special reference to entero-Behçet's syndrome. Stomach and Intestine 10 (1975) 1593–1600

    Google Scholar 

  33. Tsuji S, Y Suzuki, M Tomii, Y Matsuoka, H Kishimoto, S Irimajiri: Behçet's disease associated with multiple cerebral aneurysms and downhill esophageal varices caused by superior vena cava obstruction: A case report. Ryumachi 30 (1990) 375–381

    Google Scholar 

  34. Yamana K, K Kosuga, H Kinoshita, K Uroguchi, T Kinoshita, T Hirata, H Akashi, T Nakayama, K Ohiski: Vasculo-Behçet's disease: Immunological study of the formation of aneurysm. J Cardiovasc Surg 29 (1988) 751–755

    Google Scholar 

  35. Wolf SM, DL Schotland, LL Philips: Involvement of nervous system in Behçet's syndrome. Arch Neurol 12 (1965) 315–325

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ildan, F., Göçer, A.I., Baĝdatoĝlu, H. et al. Intracranial arterial aneurysm complicating Behçet's disease. Neurosurg. Rev. 19, 53–56 (1996). https://doi.org/10.1007/BF00346612

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00346612

Keywords

Navigation