Abstract
The purpose of this study was to evaluate the healing of an experimental left-sided colonic anastomosis in rats protected by an end diverting proximal colostomy. The anastomoses were studied by radiological and biochemical examination and breaking strength was estimated. The results were compared with a non-operated group and with a group of rats having a non-defunctional anastomosis constructed in the same manner. In animals with an end diverting colostomy, anastomotic protein levels and enzymic activity were lower than in those with a colostomy, and the development of anastomotic strength was delayed compared with those not defunctioned.
Résumé
Le but de cette étude est d'évaluer la guérsion d'une anastomose colique gauche expérimentale réalisée chez le rat sous le couvert d'une colostomie proximale terminale. Les anastomoses ont fait l'objet d'études radiologique, biolochimique et mécanique. Les résultats ont été comparés avec un groupe non opéré et avec un groupe de rats chez lesquels une colostomie non excluante avait été réalisée de la même manière. Chez les animaux avec une colostomie terminale excluante, la concentration de protéines au niveau de l'anastomose et l'activité enzymatique était inférieure à celle observée chez ceux qui avaient une colostomie non excluante; la résistance mécanique de l'anastomose était retardée en comparaison avec ceux qui avaient une colostomie non excluate.
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Bielecki, K., Grotowski, M. & Kalczak, M. Influence of proximal end diverting colostomy on the healing of left-sided colonic anastomosis: an experimental study in rats. Int J Colorect Dis 10, 193–196 (1995). https://doi.org/10.1007/BF00346217
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DOI: https://doi.org/10.1007/BF00346217