Abstract
A series of congenic mice on the BALB/c genetic background have been employed to localize a teratocarcinoma transplantation rejection locus, Gt-1, to the K side of the H-2 locus on chromosome 17. Previous studies have placed the Gt-1 sv allele about 8 centimorgans away from the H-2 b or H-2 bv1 locus. Teratocarcinomas derived from 129/sv mice, Gt-1 sv (H-2K bv1/H-2D bv1), are rejected by BALB/c (H-2K d/H-2Dd) and BALB-G mice (H-2K d/H2D-b, but form tumors in BALB-B (H-2K b/H2D b) and BALB/5R5 mice (H-2K b/H2D d). In the reciprocal tumor-rejection test, a BALB/c teratocarcinoma was rejected by immunized BALB·B mice, but formed tumors in the immunized isogenic BALB/c mouse. These studies demonstrate the reciprocal expression of two Gt-1 alleles, one Gt-1 c, in BALB/c mice, and the other, Gt-1 sv, in the congenic BALB·B mice. Shedlovsky and co-workers have placed the Gt-1 locus in a similar location on the K side of the H-2 locus on chromosome 17.
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References
Artz, K. and Jacob, F.: Absence of serologically detectable H-2 on primitive teratocarcinoma cells in culture. Transplantation 17: 633–634, 1974
Avner, P. R., Dove, W. F., Dubois, P., Gaullard, J. A., Guenet, K., Jacob, F., Jakob, H., and Shedlovsky, A.: The genetics of teratocarcinoma transplantation: Tumor formation in allogeneic hosts by the embryonal carcinoma cell lines F9 and Pcc3. Immunogenetics 7: 103–115, 1978
Bennett, D., Boyse, E. A., and Old, L. J.: Cell surface immunogenetics in the study of morphogenesis. In L. G. Silverstri (ed.): Proc. Third Lepetit Colloquim, p. 247. American Elsevier Publishing Co., New York, 1972
Forman, J. and Vitetta, E. S.: Absence of H-2 antigens capable of reacting with cytotoxic T-cells on a teratoma line expressing a T/t locus antigen. Proc. Natl. Acad. Sci. U.S.A. 72: 3661–3665, 1975
Freedman, A. and Lilly, F.: Properties of cell lines derived from tumors induced by Friend Virus in BALB/c and BALB/c H-2b mice. J. Exp. Med. 142: 212–233, 1975
Isa, A. M.: Lack of demonstrable H-2 antigens on the surface of teratocarcinoma 402AX of the mouse maintained in vivo. Transplantation 21: 196–198, 1976
Kahn, B. W. and Ephrussi, B.: Developmental potentialities of clonal in vitro cultures of mouse testicular teratomas. J. Natl. Cancer Inst. 44: 1015, 1970
Kleinsmith, L. J. and Pierce, Jr., G. B.: Multipotentiality of single embryonal carcinoma cells. Cancer Res. 24: 1544, 1964
Mintz, B. and Illmensee, K.: Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proc. Natl. Acad. Sci. U.S.A. 72: 3585–3589, 1975
Nicholas, J. F., Dubois, P., Jakob, H. Gallard, J., and Jacob, F.: Teratocarcinoma to source: Differentiation en culture d'une ligrée de cellules primitives à potentialities multiples. Ann. Microbiol. (Paris) 126A: 3–22, 1975
Pierce, Jr., G. B.: Teratocarcinoma: Induction and perspectives. In M. T. Sherman and D. Solter (eds.): Teratomas and Differentiation, pp. 3–12, Academic Press, New York, 1975
Rajan, T. V.: Glyoxalase I activitiy in H-2 b and H-2 d cells. Immunogenetics 9: 67–75, 1979
Rosenthal, M. D., Wishnow, R. M., and Sato, G. H.: In vitro growth and differentiation of clonal populations of multiple mouse cells derived from a transplantable testicular teratocarcinoma. J. Natl. Cancer Inst. 44: 1001, 1970
Siegler, E. L., Tick, N., Teresky, A. K., Rosenstraus, M., and Levine, A. J.: Teratocarcinoma transplantation rejection loci: An H-2 linked tumor rejection locus. Immunogenetics 9: 207–220, 1979
Shedlovsky, A., Clipson, L., VandeBerg, J., and Dove, W.: Strong teratocarcinoma transplantation loci, Gt-1 and Gt-2, flank H-2. Immunogenetics 13: 413–419 1981
Staats, J.: Standardized nomenclature for inbred strains of mice: Sixth listing. Cancer Res. 36: 4333–4377, 1976
Stein, P. L., Martin, G. R., and Evans, M. J.: Cell surface antigens of clonal teratocarcinoma cells at various stages of differentiation. Cell 6: 455–465, 1975
Stevens, L. C. and Little, C. C.: Spontaneous testicular teratomas in an inbred strain of mice. Proc. Natl. Acad. Sci. U. S. A. 40: 1080–1087, 1954
Stevens, L. C.: Studies on transplantable testicular teratomas of strain 129 mice. J. Natl. Cancer Inst. 20: 1257, 1958
Stevens, L. C.: Experimental production of testicular teratomas in mice of strain 129, A/He, and their F1 hybrids. J. Natl. Cancer Inst. 44: 923–929, 1970
Stevens, L. C.: The development of teratomas from parthenogenetically activated ovarian mouse eggs. In M. I, Sherman and D. Solter (eds.): Teratomas and Differentiation, pp. 17–32, Academic Press, New York, 1975
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Levine, A.J., Teresky, A.K. Teratocarcinoma transplantation rejection loci: Genetic localization of the Gt-1 locus on chromosome 17 and the expression of alternate alleles. Immunogenetics 13, 405–412 (1981). https://doi.org/10.1007/BF00346021
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DOI: https://doi.org/10.1007/BF00346021