Summary
The structure of the interneuronal connections of the mammalian spinal cord is considered and the degeneration of the boutons or endfeet of Held and Auerbach is described. Degeneration of the boutons provides a method that has been advocated and used for tracing fiber tracts to their termination wuhin the central grey matter. The validity of this method has been questioned by some and these objections are discussed. Evidence is presented that the bouton represents a locus of especial sensitivity to forward degeneration and is protected from retrograde changes, and bouton degeneration is shown to be correlated with functional and biochemical disturbances.
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This paper was written as a tribute in honour of the 80th birthday of Professor Albrecht Bethe.
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Hoff, E.C. Interneuronal connections of the mammalian spinal cord and their examination by experimental degeneration; a review of more recent findings. Zeitschrift für Zellforschung 37, 184–195 (1952). https://doi.org/10.1007/BF00345073
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DOI: https://doi.org/10.1007/BF00345073