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A review of major histocompatibility complex-disease associations in man and dog

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Abstract

The organization and biology of the Major Histocompatibility Complexes (MHC) of man (HLA) and dog (DLA) are reviewed, and a summary is presented of laboratory techniques used to define allotypes.

The nomenclature of this field and the mechanisms of disease association with the MHC are discussed. Currently recognized HLA-disease associations are enumerated, with emphasis on the value of the complement C4 marker.

DLA-disease association studies into autoimmune disease, allergy and neoplasia are reviewed.

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Authors and Affiliations

  1. Division of Veterinary Biology, School of Veterinary Studies, Murdoch University, Murdoch, Western Australia, (Australia)

    M. J. Day & W. J. Penhale

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  1. M. J. Day
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  2. W. J. Penhale
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Day, M.J., Penhale, W.J. A review of major histocompatibility complex-disease associations in man and dog. Veterinary Research Communications 11, 119–132 (1987). https://doi.org/10.1007/BF00344944

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