Skip to main content
SpringerLink
Log in

Vesicles of fenestrated and non-fenestrated endothelium

  • Published:
Zeitschrift für Zellforschung und Mikroskopische Anatomie Aims and scope Submit manuscript

Summary

The morphology of the three types of endothelial vesicles in fenestrated and non-fenestrated capillaries from various sources (human skin, senile dermal angiomas, frog tongue and rat renal medulla) has been studied. The micropinocytotic vesicles of Palade were prevalent in the non-fenestrated endothelium with most caveolae closed by either amorphous material of low electron density or a caveolar membrane. The initial stage of the opening of vesicles onto the surface plasma membrane and the terminal stages of separation were indefinite. Those vesicles which were fusing with or separating from adjacent vesicles displayed amorphous material or an intervesicular membrane at the line of junction. Such features were present irrespective of the relationship of the vesicles to the plasma membrane and of the fenestration of the endothelium. The caveolar and intervesicular membranes vary in morphology as do those bridging the conventional fenestrae.

Macropinocytotic vesicles were most numerous in vessels of the senile angioma and in the frog tongue. Membranes were observed closing caveolae of the relatively uncommon coated or dense-walled pinocytotic type.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Bennett, H. S., J. H. Luft, and J. C. Hampton: Morphological classifications of vertebrate blood capillaries. Amer. J. Physiol. 196, 381–390 (1959).

    Google Scholar 

  • Bruns, R. R., and G. E. Palade: Studies on capillaries. I. General organization of blood capillaries in muscle. J. Cell Biol. 37, 244–276 (1968a).

    Google Scholar 

  • —: Studies on blood capillaries. II. Transport of ferritin molecules across the wall of muscle capillaries. J. Cell Biol. 37, 276–299 (1968b).

    Google Scholar 

  • Elfvin, L. G.: The ultrastructure of the capillary fenestrae in the adrenal medulla of the rat. J. Ultrastruct. Res. 12, 687–704 (1965).

    Google Scholar 

  • Fawcett, D. W.: Comparative observations on the fine structure of blood capillaries. In: The peripheral blood vessels, ed. by J. L. Orbison and D. Smith, p. 17–44. Baltimore: Williams & Wilkins Co. 1963.

    Google Scholar 

  • Florey, Lord: The missing link. Quart. J. exp. Physiol. 53, 1–5 (1968).

    Google Scholar 

  • Jennings, M. A., and Lord Florey: An investigation of some properties of endothelium related to capillary permeability. Proc. roy. Soc. B 167, 39–63 (1967).

    Google Scholar 

  • Karnovsky, M. J.: The ultrastructural basis of capillary permeability studied with peroxidase as a tracer. J. Cell Biol. 35, 213–236 (1967).

    Google Scholar 

  • Karrer, H. E.: The striated musculature of blood vessels. II. Cell interconnections and cell surface. J. biophys. biochem. Cytol. 8, 135–150 (1960).

    Google Scholar 

  • Luft, J. H.: The ultrastructural basis of capillary permeability. In: The inflammatory process, p. 121–159. New York: Academic Press, Inc. 1965.

    Google Scholar 

  • Majno, G.: Ultrastructure of the vascular membrane. In: Handbook of physiology, vol. III, p. 2292–2375. Washington, D. C.: Am. Physiological Society 1965.

    Google Scholar 

  • Odland, G. G.: The fine structure of cutaneous capillaries. In: Advances in biology of skin, vol. II p. 57. London: Pergamon Press 1961.

    Google Scholar 

  • Palade, G. E.: Fine structure of blood capillaries. J. appl. Physics 24, 1424 (1953).

    Google Scholar 

  • Rhodin, J. A. G.: The diaphragm of capillary endothelial fenestrations. J. Ultrastruct. Res. 6, 171–185 (1962).

    Google Scholar 

  • Stehbens, W. E.: Ultrastructure of vascular endothelium in the frog. Quart. J. exp. Physiol. 50, 375–384 (1965a).

    Google Scholar 

  • —: Endothelial vesicles and protein transport. Nature (Lond.) 207, 197–198 (1965b).

    Google Scholar 

  • —, and R. M. Ludatscher: Fine structure of senile angiomas of human skin. Angiology 19, 581–592 (1968).

    Google Scholar 

  • White, J. G., and C. C. Clawson: Blood cells and blood vessels. In: Ultrastructure of normal and abnormal skin, by A. S. Zelickson, p. 280–298. Philadelphia: Lea & Febiger 1967.

    Google Scholar 

  • Zetterqvist, H.: The ultrastructural organization of the columnar absorbing cells of the mouse jejunum. Thesis. Stockholm: Dept. Anat., Karolinska Institutet 1965.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Washington University School of Medicine and Jewish Hospital of St. Louis, USA

    Ruth M. Ludatscher &  William E. Stehbens

  2. Department of Pathology, Veterans Administration Hospital, 12208, Albany, New York, USA

    William E. Stehbens

Authors
  1. Ruth M. Ludatscher
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. William E. Stehbens
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work was supported by the General Research Fund of the Jewish Hospital of St. Louis.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ludatscher, R.M., Stehbens, W.E. Vesicles of fenestrated and non-fenestrated endothelium. Z. Zellforsch. 97, 169–177 (1969). https://doi.org/10.1007/BF00344755

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00344755

Keywords

Search

Navigation