Summary
Differences in frequency of postmyelographic adverse reactions were analyzed with respect to sex and age in a prospective study including 1026 patients injected with metrizamide and 739 injected with iohexol. Regardless of the type of contrast medium or myelography, all types of adverse reactions were 1.4–3.8 times as frequent in women as in men. Most of the differences were statistically significant. Headache was more frequent, while vomiting and dizziness were less frequent in both women and men aged 26–50 years compared with those over 50 years of age. Dizziness and increased low back pain were consistently reported spontaneously by the patients less frequently than emerged via formal interview. The large differences between the sexes suggest that further research on contrast media toxicity would be best performed with separation of the data by gender.
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References
Skalpe IO (1971) Lumbar myelography with Conray Meglumin 282. Acta Neurol Scand 47:569–578
Tourtellotte WW, Henderson WG, Tucker RP, Gilland O, Walker JE, Kokman E (1972) A randomized, double-blind clinical trial comparing the 22 versus 26 gauge needle in the production of the post-lumbar puncture syndrome in normal individuals. Headache 12:73–78
3.Skalpe IO, Amundsen P (1975) Thoracic and cervical myelography with metrizamide. Radiology 116:101–106
Skalpe IO, Amundsen P (1975) Lumbar radiculography with metrizamide. Radiology 115:91–95
Belloni G, Bonaldi G, Moschini L, Quilici N (1981) Cervical myelography with iopamidolo. Neuroradiology 21:97–99
Shaw DD, Bach-Gansmo T, Dahlström K: Iohexol (1985) Summary of North American and European clinical trials in adult lumbar, thoracic and cervical myelography with a new nonionic contrast medium. Invest Radiol [Suppl] 20:S44-S50
Latchaw RE, Hirsch WL Jr, Horton JA, Bissonette D, Shaw DD (1985) Iohexol vs metrizamide: study of efficacy and morbidity in cervical myelography. AJNR 6:931–933
Kendall B (1986) Iohexol in paediatric myelography. An open non-comparative trial. Neuroradiology 28:65–68
Skalpe IO, Nakstad P (1988) Myelography with iohexol (omni-paque); a clinical report with special reference to the adverse effects. Neuroradiology 30:169–174
Wilmink JT, Lindeboom SF, Vencken LM, Burg W v d (1984) Relationship between contrast medium dose and adverse effects in lumbar myelography. Diagn Imag Clin Med 33: 208–214
Nakstad P, Helgetveit A, Aaserud O, Ganes T, Nyberg-Hansen R (1984) Iohexol compared to metrizamide in cervical and thoracic myelography. A randomized double blind parallel study. Neuroradiology 26:479–484
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Maly, P. Sex and age related differences in postmyelographic adverse reactions. Neuroradiology 31, 331–335 (1989). https://doi.org/10.1007/BF00344177
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DOI: https://doi.org/10.1007/BF00344177