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Mouse candidiasis

II. Host responses are T-cell dependent and regulated by genes in the major histocompatibility complex

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Abstract

Administration of a Thy-1.2-specific monoclonal antibody to BALB/c mice resulted in a significant decrease in the efficiency of clearance of Candida albicans from the spleen. The rate of clearance of organisms from the spleen of congenic mice was determined by genes in the major histocompatibility complex, as was the magnitude of the inflammatory response in the popliteal lymph node after footpad immunization. These results formally demonstrate the involvement of T cells in host responses to primary candida infection.

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References

  • Bistoni, F., Marconi, P., Frati, L., Bonmassor, E., and Garaci, E.: Increase of mouse resistance to Candida albicans infection by thymosin α1. Infect. Immun. 36: 609–614, 1982

    Google Scholar 

  • Bistoni, F., Vecchiarelli, A., Cenci, E., Puccetti, P., Marconi, P., and Cassone, A.: Evidence for macrophage-mediated protection against lethal Candida albicans infection. Infect. Immun. 51: 668–674, 1986

    Google Scholar 

  • Bodey, G. P.: Candidiasis in cancer patients. Am. J. Med. 2 suppl. 4D: 13–19, 1984

    Google Scholar 

  • Carrow, E. W. and Domer, J. E.: Immunoregulation in experimental murine candidiasis: Specific suppression induced by Candida albicans cell wall glycoprotein. Infect. Immun. 49: 172–181, 1985

    Google Scholar 

  • Cheers, C. and Waller, R.: Activated macrophages in congenitally athymic “nude” mice and in lethally irradiated mice. J. Immunol. 115: 844–847, 1975

    Google Scholar 

  • Clift, R. A.: Candidiasis in the transplant patient. Am. J. Med. 2 (suppl. 4D): 34–38, 1984

    Google Scholar 

  • Cutler, J. E.: Acute systemic candidiasis in normal and congenitally thymic deficient (nude) mice. J. Reticuloendothel. Soc. 19: 121–126, 1976

    Google Scholar 

  • Dausset, J. and Svejgaard, A. (eds.): HLA and Disease, p. 1–316, Munksgaard, Copenhagen, 1977

    Google Scholar 

  • Giger, R. K., Domer, J. E., and McQuitty, J. T., Jr.: Experimental murine candidiasis: Pathological and immune responses to cutaneous inoculation with Candida albicans. Infect. Immun. 19: 499–509, 1978a

    Google Scholar 

  • Giger, D. K., Domer, J. E., Moser, S. A., and McQuitty, J. T., Jr.: Experimental murine candidiasis: Pathological and immune responses in T-lymphocyte-depleted mice. Infect. Immun. 21: 729–737, 1978b

    Google Scholar 

  • Hector, R. F., Domer, J. E., and Carrow, E. W.: Immune responses to Candida albicans in genetically distinct mice. Infect. Immun. 38: 1020–1028, 1982

    Google Scholar 

  • Hurtrel, B. and Lagrange, P. H.: Dissociation between cell-mediated immunity and acquired resistance in systemic murine candidiasis. Ann. Immunol. (Paris) 136D: 29–36, 1985

    Google Scholar 

  • Hurtrel, F., Lagrange, P. H., and Michel, A.: Absence of correlation between delayed-type hypersensitivity and protection in experimental systemic candidiasis in immunised mice. Infect. Immun. 31: 95–101, 1981

    Google Scholar 

  • Kirkpatrick, C. H.: Host factors in defense against fungal infections. Am. J. Med. 2 (suppl. 4D): 1–12, 1984

    Google Scholar 

  • Ledbetter, J. A. and Herzenberg, L. A.: Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol. Rev. 47: 63–90, 1979

    Google Scholar 

  • Louria, D. B.: Candida infection in experimental animals In G. P. Bodey and V. Fainstein (eds.): Candidiasis, pp. 29–51, Raven Press, New York, 1985

    Google Scholar 

  • Maiti, P. K., Kumar, A., Kumar, R., and Mohapatra, L. N.: Role of anti-bodies and effect of BCG vaccination in experimental candidiasis in mice. Mycopathalogica 91: 79–85, 1985

    Google Scholar 

  • Marra, S. and Balish, E.: Immunity to Candida albicans induced by listeria monocytogenes. Infect. Immun. 10: 72–82, 1974

    Google Scholar 

  • Miyake, T., Takeyo, K., Nomoto, K., and Muraoka, J.: Cellular elements in the resistance to Candida infection in mice. I. Contribution of T lymphocytes and phagocytes at various stages of infection. Microbiol. Immunol. 21: 703–725, 1977

    Google Scholar 

  • Odds, F. C.: Candida and Candidosis. University Park Press, Baltimore, 1979

    Google Scholar 

  • Pearsall, N. N., Adams, B. L., and Bunni, R.: Immunologic responses to Candida albicans. III. Effects of passive transfer of lymphoid cells or serum on murine candidiasis. J. Immunol. 120: 1176–1180, 1978

    Google Scholar 

  • Rifkind, D., Marchioro, T. L., Schneck, S. A., and Hill, R. B.: Systemic fungal infections complicating renal transplantation and immunosuppressive therapy. Am. J. Med. 43: 28–38, 1967

    Google Scholar 

  • Rogers, T. J. and Balish, E.: Immunity to Candida albicans. Microbiol. Rev. 44: 660–682, 1980

    Google Scholar 

  • Rogers, T. J., Balish, E., and Manning, D. D.: The role of thymus-dependent cell-mediated immunity in resistance to experimental disseminated candidiasis. J. Reticuloendothel. Soc. 20: 291–298, 1976

    Google Scholar 

  • Salvin, S. B., Peterson, R. D. A., and Good, R. A.: The role of the thymus in resistance to infection and endotoxin toxicity. J. Lab. Clin. Med. 65: 1004–1022, 1965

    Google Scholar 

  • Stenderup, A. and Schonheyder, H.: Mycoses complicating AIDS. Microbiol. Sci. 1: 219–223, 1984

    Google Scholar 

  • Stobo, J., Hull, S., VanScoy, R., and Hermans, P.: Suppressor thymusderived lymphocytes in fungal infection. J. Clin. Invest. 57: 319–328, 1976

    Google Scholar 

  • Tabeta, H., Mikami, Y., Abe, F., Ommura, Y., and Arai, T.: Studies on defense mechanisms against Candida albicans infection in congenitally athymic nude (nu/nu) mice. Mycopathologica 84: 107–113, 1984

    Google Scholar 

  • Wade, J. C. and Schimpff, S. C.: Epidemiology and prevention of candida infections. In G. P. Bodey and V. Fainstein (eds.): Candidiasis, pp. 111–133, Raven Press, New York, 1985

    Google Scholar 

  • Williams, D., Cook, J., Hoffman, E., and Diluzio, N.: Protective effect of glucan in experimentally induced candidiasis. J. Reticuloendothel. Soc. 23: 479–490, 1978

    Google Scholar 

  • Zinkernagel, R. M., Leist, T., Hengartner, H., and Althage, A.: Susceptibility to lymphocytic choriomeningitis virus isolates correlates directly with early and high cytotoxic T cell activity, as well as with footpad swelling reaction, and all three are regulated by H-2D. J. Exp. Med. 162: 2125–2141, 1985a

    Google Scholar 

  • Zinkernagel, R. M., Pfau, C. J., Hengartner, H., and Althage, A.: Susceptibility to routine lymphocytic choriomeningitis virus maps to class 1 MHC genes — A model for MHC/disease associations. Nature 316: 814–817, 1985b

    Google Scholar 

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  1. Clinical Immunology Research Unit, Princess Margaret Hospital, Thomas Street, 6008, Subiaco, Western Australia

    R. B. Ashman

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  1. R. B. Ashman
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Ashman, R.B. Mouse candidiasis. Immunogenetics 25, 200–203 (1987). https://doi.org/10.1007/BF00344035

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  • DOI: https://doi.org/10.1007/BF00344035

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