Summary
Sleep disturbances, which are a prominent symptom of depressive illness, were analyzed in endogenously depressed patients during depression and during full remission. These disturbances may be described at the level of sleep stages, at the level of the sleep profile, and at the level of consecutive sleep records.
The scoring of sleep stages in sleep records of depressive patients provides difficulties, because the temporal coherence of different electrophysiological descriptors of sleep is weakened during depression. The sleep profile of depressed patients is characterized by alterations in the normal sequence of sleep stages and frequent stage changes. The disturbances in the sleep profile are unstable in that they show marked day to day fluctuations. It could be shown in some patients that there is a correlation between parameters of the first REM sleep phase and urinary free cortisol excretion in corresponding nights.
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References
Atkinson, M., Kripke, D. F., Wolf, S. R.: Autorhythmometry in Manic-Depressives. Chronobiologia 2, 325–335 (1975)
Coble, P., Foster, F. G., Kupfer, D. J.: Electroencephalographic sleep diagnosis of primary depression. Arch. Gen. Psychiatry 33, 1124–1127 (1976)
Dirlich, G., Schulz, H., Lund, R.: Increase of SOREMP frequency in endogeneous depression. Association for the Psychophysiological Study of Sleep, 18th Annual Meeting, April 5–9, 1978, Palo Alto, Calif., USA
Hauri, P., Hawkins, D. R.: Alpha-delta-sleep. Electroencephalogr. Clin. Neurophysiol. 34, 233–237 (1973)
Kupfer, D. J.: REM Latency: a psychobiologic marker for primary depressive disease. Biol. Psychiatry 11, 159–174 (1976)
Mendelson, W. B., Gillin, J. C., Wyatt, R. J. (Eds.): Human sleep and its disorders. New York: Plenum Press 1977
Pflug, B., Erikson, R., Johnson, A.: Depression and daily temperature. Acta Psychiatr. Scand. 54, 254–266 (1976)
Rechtschaffen, A., Kales, A. (Eds.): A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Washington, D. C.: U. S. Government Printing Office (Public Health Service) 1968
Sachar, E. J., Hellman, L., Roffwarg, H. P., Halpern, F. X., Fukushima, D. K., Gallagher, T. F.: Disrupted 24-hour patterns of cortisol secretion in psychotic depression. Arch. Gen. Psychiatry 28, 19–24 (1973)
Williams, R. L., Karacan, I., Hursch, C. J.: Electroencephalography (EEG) of human sleep: Clinical applications. New York: Wiley 1974
Zerssen, D. v., Koeller, D.-M.: Klinische Selbstbeurteilungs-Skalen (KSb-S) aus dem Münchner Psychiatrischen Informations-System (Psychis München). Manuale. Weinheim: Beltz 1976
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The authors are members of a research group studying depression at the MPI for Psychiatry, Munich
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Schulz, H., Lund, R. & Doerr, P. The measurement of change in sleep during depression and remission. Arch. Psychiat. Nervenkr. 225, 233–241 (1978). https://doi.org/10.1007/BF00344010
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DOI: https://doi.org/10.1007/BF00344010