Summary
CSF/serum albumin and immunoglobulin G ratios were determined in 520 patients suffering from various neurological diseases. Blood-brain barrier impairment was detectable in most cases of spinal tumour, meningitis, Guillain-Barré syndrome and in two-thirds of the patients with cerebral infarctions. A local IgG formation in the CNS has to be assumed for some cases of meningitis considering the course of the protein dysequilibrium. Autochthonous IgG production together with a barrier dysfunction was found in patients with encephalitis, meningoradiculitis and neurosyphilis. In cases of multiple sclerosis local IgG formation in the CNS was the pre-dominant finding.
Zusammenfassung
Die Liquor/Serum-Konzentrationsquotienten für Albumin und Immunglobulin G wurden bei 520 Patienten mit unterschiedlichen neurologischen Erkrankungen bestimmt. Eine Störung der Blut-Liquor Schranke hatten die meisten Patienten mit spinalen Tumoren, Meningitiden, Polyradiculitiden und zwei Drittel der Fälle mit Hirninfarkten. Eine lokale IgG-Synthese im Zentralnervensystem muß für einen Teil der Patienten mit Meningitiden angenommen werden. Eine autochthone IgG Bildung zusammen mit einer Blut-Liquorschrankenstörung fanden wir bei Enzephalitiden, Meningoradiculitiden und der Lues cerebrospinalis. Die lokale IgG Produktion war der vorherrschende Befund bei der multiplen Sklerose.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Abramsky O, Webb C, Teitelbaum D, Arnon R (1975) Cell-mediated immunity to neural antigens in idiopathic polyneuritis and myeloradiculitis. Neurology 25: 1154–1159
Busse O (1982) Zur Prognose des ischämischen Hirninfarkts. Fortschr Med 100: 1197–1200
Cook SD, Dowling PC, Murray PR, Whitacker JN (1971) Circulating demyelinating factors in acute idiopathic polyneuropathy. Arch Neurol 24: 136–144
Delmotte P (1971) Gel isoelectric focusing of cerebrospinal fluid proteins: a potential diagnostic tool. Z Klin Chem Klin Biochem 9: 334–336
Eickhoff K, Wikström J, Poser S, Bauer H (1977) Protein profile of cerebrospinal fluid in multiple sclerosis with special reference to the function of the blood-brain barrier. J Neurol 214: 207–215
Felgenhauer K, Schliep G, Rapic N (1976) Evaluation of the blood-CSF barrier by protein gradients and the humoral immune response within the central nervous system. J Neurol Sci 30: 113–128
Ganrot K, Laurell CB (1974) Measurement of IgG and albumin content of cerebrospinal fluid, and its interpretation. Clin Chem 20: 571–573
Ganrot-Norlin K (1978) Relative concentrations of albumin and IgG in cerebrospinal fluid in health and acute meningitis. Scand J Infect Dis 10: 57–60
Link H, Wahren B, Norrby E (1979) Pleocytosis and immunoglobulin changes in cerebrospinal fluid and herpesvirus serology in patients with Guillain-Barré syndrome. J Clin Microbiol 9: 305–316
Lisak RP, Zwiman B, Norman M (1975) Antimyelin antibodies in neurological diseases. Arch Neurol 32: 163–167
Nyland H, Aarli JA (1978) Guillain-Barré syndrome: Demonstration of antibodies to peripheral nerve tissue. Acta Neurol Scand 58: 35–43
Reiber H (1980) The discrimination between different blood-CSF barrier dysfunctions and inflammatory reactions of the CNS by a recent evaluation graph for the protein profile of cerebrospinal fluid. J Neurol 224: 89–99
Sayk J (1981) Liquorbefunde. In: Hopf HCh, Poeck K, Schliack H (Hrsg) Neurologie in Praxis und Klinik, Bd II. Georg Thieme, Stuttgart New York, S 440–450
Schliep G, Felgenhauer K (1978) Serum-CSF protein gradients, the blood-CSF barrier and the local immune response. J Neurol 218: 77–96
Sears S, McCammon A, Bigelow R, Hayman A (1982) Maximizing the harvest of contrast enhancing lesions in multiple sclerosis. Neurology 32: 815–820
Vedeler CA, Nyland H, Fagius J, Osterman PO, Matre R, Aarli JA, Janzen RWC, Jacobsen H, Skre H (1982) The clinical effect and the effect on serum IgG antibodies to peripheral nerve tissue of plasma exchange in patients with Guillain-Barré syndrome. J Neurol 228: 59–64
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hornig, C.R., Busse, O. & Dorndorf, W. Protein pattern of cerebrospinal fluid in various neurological diseases. Arch Psychiatr Nervenkr 233, 253–262 (1983). https://doi.org/10.1007/BF00343600
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00343600