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Histocompatibility antigens in primary affective disorders

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Summary

We determined 27 histocompatibility antigens of A, B, and C locus with a standard lymphocyte cytotoxicity test in 125 patients suffering from primary affective disorders, 77 of bipolar type, 24 of unipolar type, and 24 with schizo-affective psychosis. Comparison with a normal control group showed significant increases in the frequencies of antigens Bw40 and Cw4 in unipolar patients and a significantly decreased frequency of antigen Cw3 in bipolar patients. The statistical significances, which were at the 5% level, disappeared when the P values were corrected for the number of antigens investigated. Our results failed to confirm previous findings of significantly altered antigen frequencies among patients with primary affective disorders.

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Authors and Affiliations

  1. Psychiatric Research Unit, Charles University, Prague, Czechoslovakia

    P. Zvolský, M. Dvořáková, A. Májský & K. Souček

  2. Institute of Haematology and Blood Transfusion, Prague, Czechoslovakia

    P. Zvolský, M. Dvořáková, A. Májský & K. Souček

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  1. P. Zvolský
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  2. M. Dvořáková
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  3. A. Májský
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  4. K. Souček
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Zvolský, P., Dvořáková, M., Májský, A. et al. Histocompatibility antigens in primary affective disorders. Arch. Psychiat. Nervenkr. 225, 159–162 (1978). https://doi.org/10.1007/BF00343399

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  • DOI: https://doi.org/10.1007/BF00343399

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