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Photic EEG-driving responses in thalamotomized and medicated cases of Parkinson's disease

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Summary

EEG-driving responses to visual stimulation were studied using EEG Interval Spectrum Analysis (EISA) before and after stereotaxic thalamotomy and Nacom® (L-Carbidopa and Levodopa) treatment of 67 Parkinson patients. Five types of photic-driving responses were distinguished in the EISA results: (1) all-band response, (2) Beta-dominant, (3) Alpha-Betadominant, (4) Alpha-Theta-dominant, (5) non-response.

Twenty patients received a daily dose of 750–1000 mg of Nacom orally, and 47 patients 1000–1500 mg for a period of 3 to 4 weeks. In most cases the medication produced no change in photic-driving and EEG patterns. The photic-driving response showed no significant correlation with clinical signs and background EEG.

Unilateral thalamotomy was performed in ten Parkinson patients. In two of these patients the EEG-driving response diminished in the first postoperative week for low frequency stimuli but increased after the second week.

Zusammenfassung

Die EEG-Lichtreaktion auf periodische Lichtblitze von 4–26/s, analysiert mit der EEG-Intervall-Spektrum-Analyse (EISA), wurde vor und nach Behandlung von 67 Parkinson-Patienten untersucht.

Die verschiedenen Muster der Lichtreaktionen wurden in 5 Gruppen eingeteilt: (1) Reaktion auf der gesamten Bandbreite, (2) Beta-dominante Reaktion, (3) Alpha-Beta-dominante Reaktion, (4) Alpha-Theta-dominante Reaktion, (5) keine Reaktion.

Die 67 Parkinson-Patienten erhielten L-carbidopa und Levodopa (Nacom, Sharp & Dohme) in therapeutischer Dosierung. Zwanzig Patienten bekamen eine tägliche Dosis von 750–1500 mg/die, für 3–4 Wochen. Bei der Mehrzahl der Fälle bewirkte die Medikation keine Veränderung der Lichtreaktion und des EEG. Eine signifikante Korrelation von klinischen Zeichen und Hintergrunds-EEG zur Lichtreaktion fand sich nicht.

Bei 10 Patienten wurde eine unilaterale Thalamotomie vorgenommen. Bei zwei dieser Patienten verminderte sich die Lichtreaktion für niederfrequente Reize in der ersten postoperativen Woche, nahm jedoch nach der zweiten Woche wieder zu.

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Author notes

  1. ChangRak Choi

    Present address: Department of Neurosurgery, St. Mary's Hospital, Catholic Medical School, Seoul, Korea

Authors and Affiliations

  1. Neurochirurgische Universitätsklinik Klinikum Steglitz der Freien Universität Berlin, Deutschland

    ChangRak Choi

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  1. ChangRak Choi
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Fellow of the Alexander-von-Humboldt-Foundation, M.D., Ph.D., M.S.

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Choi, C. Photic EEG-driving responses in thalamotomized and medicated cases of Parkinson's disease. Arch. Psychiat. Nervenkr. 225, 97–105 (1978). https://doi.org/10.1007/BF00343393

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  • DOI: https://doi.org/10.1007/BF00343393

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