Summary
A double blind study was carried out to evaluate safety, tolerability and visualization quality of the non-ionic contrast medium Iohexol compared to Meglumine-Ca-Metrizoate (Isopaque Cerebral) for cerebral angiography. The two contrast media were found equal in most respects. A slight increase in systolic blood pressure following Meglumine-Ca-Metrizoate injections and a slight decrease in diastolic blood pressure following Iohexol were statistically significant. Tachycardia following injections of Meglumine-Ca-Metrizoate in the aortic arch was also significant and may indicate more discomfort from this medium, although no difference was found in patient interviews. The changes in blood pressure and heart rate were small and of no clinical importance.
Similar content being viewed by others
References
Iohexol (1980) A non-ionic contrast medium. Pharmacology and toxicology. Acta Radiol [Suppl] 362
Levorstad K, Kolbenstvedt A, Sommerfelt S Chr, Egeblad M, Thrane Nielsen N, Sjøberg S, Olbring Y, Zahrisson B, Jagenburg R, Sveen K (1982) Tolerability and diagnostic usefulness of iohexol in human urography. Submitted to Acta Radiol
Levorstad K, Simonsen S, Skrede M, Orning O, Tylén U, Olsson L, Selin K, Dahlstrøm K, Andrew E (1982) Tolerability and diagnostic usefulness of iohexol in human cardioangiography. Submitted to Acta Radiol
Amundsen P, Dugstad B, Presthus Y, Ahlgren P, Cronqvist S, Holtaas S, Skalpe I, Lundervold A, Dahlstrøm K, Renaa T (1982) Cerebral angiography with iohexol, a new non-ionic contrast medium. A phase II multicentre clinical trial. Submitted to Acta Radiol
Amundsen P, Dugstad G, Presthus J (1982) Randomized double-blind cross-over study of iohexol and amipaque in cerebral angiography. Submitted to presentation at the XII. Symposium Neuroradiologicum, Washington DC, October 1982
Ahlgren P (1982) Iohexol compared to urografin meglumine in cerebral angiography. A randomized, double blind cross-over study. Neuroradiology 23:195–198
Skalpe IO, Lundervold A, Tjørstad K (1977) Cerebral angiography with non-ionic (metrizamide) and ionic (meglumine metrizoate) water soluble contrast media. A comparative study with double blind technique. Neuroradiology 14:15–19
Amundsen P, Dugstad G, Slettebø M (1978) Clinical testing of amipaque for cerebral angiography: Neuroradiology 15: 89–93
Lundervold A, Engeset A (1964) Polygraphic recordings during cerebral angiography. Acta Radiol 5:368–380
Greitz T, Törnell G (1967) Bradycardial reactions during cerebral angiography. A comparison of isopaque sodium, isopaque B, hypaque and urografin. Acta Radiol [Suppl] 270: 75–86
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nakstad, P., Sortland, O., Aaserud, O. et al. Cerebral angiography with the non-ionic water-soluble contrast medium Iohexol and Meglumine-Ca-Metrizoate. Neuroradiology 23, 199–202 (1982). https://doi.org/10.1007/BF00342540
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00342540