Summary
A 69-year-old male suffering from progressive dementia died 3 years after the beginning of his disease. The neuropathology of this case revealed the coexistence of senile changes, typical for Alzheimer's disease, and the characteristics of Parkinson's disease, namely, numerous senile plaques and neurofibrillary tangles in the cerebrum and neuronal loss with depigmentation in the substantia nigra and locus caeruleus. Lewy-type inclusions were distributed not only in the pigmented brain stem nuclei, but also diffusely in the CNS. The close nosological relationship between paralysis agitans and Alzheimer's disease is discussed.
Zusammenfassung
Ein 69jähriger Mann mit progressiver Demenz verstarb 3 Jahre nach Beginn der Erkrankung. Die Neuropathologie dieses Falles ist gekennzeichnet durch die Koexistenz bekannter seniler Veränderungen in Form von zahlreichen senilen Drüsen und Alzheimerschen Neurofibrillenveränderungen im Großhirn (Morbus Alzheimer) und leichter Nervenzellausfälle mit Depigmentation in Substantia nigra und Locus caeruleus (beginnende Paralysis agitans). Bemerkenswert ist ferner ein zahlreiches Vorkommen von Lewy-Körperchen, die nicht nur im Hirnstamm, sondern auch in den Nervenzellen der Hirnrinde verteilt sind. Die engen nosologischen Beziehungen zwischen Parkinsonscher und Alzheimerscher Krankheit werden diskutiert.
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Ikeda, K., Hori, A. & Bode, G. Progressive dementia with ‘diffuse Lewy-type inclusions’ in cerebral cortex. Arch. Psychiat. Nervenkr. 228, 243–248 (1980). https://doi.org/10.1007/BF00342349
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DOI: https://doi.org/10.1007/BF00342349