Summary
Selective left vertebral angiography was carried out in 25 rabbits comparing the toxic effects of iohexol and metrizamide (Amipaque). The iodine concentration for iohexol was 280 and 350 mg/ml and for metrizamide 350 mg/ml. Short general convulsions were seen in many of the animals with iohexol in the concentration of 350 mg iodine/ml. Cardiovascular reactions were seen with both contrast media, but were more marked with iohexol than with metrizamide in the concentration of 350 mg iodine/ml. Both iohexol and metrizamide are far less toxic than the ionic contrast medium metrizoate, but metrizamide seems to be less toxic than iohexol in vertebral angiography.
Similar content being viewed by others
References
Amundsen, P., Dugstad, G., Slettebø, M.: Clinical testing of Amipaque for cerebral angiography. Neuroradiology 15, 89–93 (1978)
Aulie, Å.: Effect of iohexol, metrizamide and ioxaglate on the blood-brain barrier. Acta Radiol. [Suppl.] 362, 13–16 (1980)
Golman, K., Olivecrona, H., Gustafson, C., Salvesen, S., Almén, T., Maly, P.: Excitation and depression of nonanaesthetized rabbits following injection of contrast media into the subarachnoid space. Acta Radiol. [Suppl.] 362, 83–86 (1980)
Gonsette, R. E.: Biologic tolerance of the central nervous system to metrizamide. Acta Radiol. [Suppl.] 335, 25–44 (1973)
Haavaldsen, J.: Iohexol. Introduction. Acta. Radiol. [Suppl.] 362, 9–11 (1980)
Lamb, J. T.: Angiography with Amipaque. Neuroradiology 16, 612–613 (1978)
Siefert, H. -M., Press, W.-R., Speck, U.: Tolerance to iohexol after intracisternal, intracerebral and intraarterial injection in the rat. Acta Radiol. [Suppl.] 362, 77–81 (1980)
Skalpe, I. O.: The toxicity of the non-ionic water-soluble contrast medium metrizamide (Amipaque) in selective vertebral angiography. An experimental study in rabbits. Neuroradiology 13, 19–24 (1977)
Skalpe, I. O., Lundervold, A., Tjørstad, K.: Cerebral angiography with non-ionic (metrizamide) and ionic (meglumine metrizoate) water-soluble contrast media. Neuroradiology 14, 15–19 (1977)
Skalpe, I. O., Lundervold, A., Tjørstad, K.: Complications of cerebral angiography. Comparing metrizamide (Amipaque) and meglumine metrizoate (Isopaque Cerebral). Neuroradiology 19, 67–71 (1980)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Skalpe, I.O. The toxicity of the non-ionic water-soluble contrast media iohexol and metrizamide (Amipaque) in selective vertebral angiography. Neuroradiology 20, 235–239 (1981). https://doi.org/10.1007/BF00342090
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00342090