Summary
The methods and results of some recent family, twin and adoption studies of childhood behaviour disorders, crime, alcoholism, psychopathic personality and neurosis are briefly described. The data of Slater (1938) on the parents and children of manic-depressives are reanalysed. Bipolar affective illnesses were more frequent in the families of bipolar than unipolar probands. There was no support for sex-linked inheritance in either group or for further genetic subdivision of the unipolar group according to age of onset or alcoholic or psychopathic family history. It is suggested that for the time being we may have to be satisfied with three broad and aetiologically overlapping clinical types of depression: bipolar, unipolar and reactive.
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Åmark, C.: A study in alcoholism. Acta psychiat. scand., Suppl. 70 (1951)
Angst, J.: Zur Ätiologie und Nosologie endogener depressiver Psychosen. Monographien aus dem Gesamtgebiete der Neurologie und Psychiatrie, Bl. 112. Berlin-Heidelberg-New York: Springer 1966
Bakwin, H.: Sleep-walking in twins. Lancet 1970 II, 446–447
Bakwin, H.: Enuresis in twins. Amer. J. Dis. Child. 121, 222–225 (1971)
Bakwin, H.: Nail-biting in twins. Develop. Med. Child Neurol. 13, 304–307 (1971)
Bakwin, H.: Persistent finger-sucking in twins. Develop. Med. Child Neurol. 13, 308–309 (1971)
Bakwin, H.: Car-sickness in twins. Develop. Med. Child Neurol. 13, 310–312 (1971)
Bakwin, H.: Beading disability in twins. Develop. Med. Child Neurol. 15, 184–187 (1973)
Bakwin, H., Davidson, M.: Constipation in twins. Amer. J. Dis. Child. 121, 179–181 (1971)
Bleuler, M.: Familial and personal background of chronic alcoholics. In: Etiology of chronic alcoholism. Ed. O. Diethelm. Springfield, Ill.: Ch. C. Thomas 1955
Carter, C. O.: Genetics of common disorders. Brit. med. Bull. 25, 52–57 (1969)
Carter, C. O., Evans, K. A.: Inheritance of congenital pyloric stenosis. J. med. Genet. 6, 233–254 (1969)
Christiansen, K. O.: Crime in a Danish twin population. Acta genet, med. (Roma) 19, 323–326 (1970)
Christiansen, K. O.: The genesis of aggressive criminality: Implications of a study of crime in a Danish twin study. In: Determinants and origins of aggressive behavior. Eds. J. de Wit and W. W. Hartup. The Hague: Mouton 1974
Cowie, J., Cowie, V., Slater, E.: Delinquency in girls. London: Heinemann 1968
Crowe, R. R.: The adopted offspring of women criminal offenders. Arch. gen. Psychiat. 27, 600–603 (1972)
Crowe, R. R.: An adoption study of antisocial personality. Arch. gen. Psychiat. 31, 785–791 (1974)
Fieve, R. R., Mendlewiez, J., Fleiss, J. L.: Manic-depressive illness: linkage with the Xg blood group. Amer. J. Psychiat. 130, 1355–1359 (1973)
Goetzl, U., Green, R., Whybrow, P., Jackson, R.: X linkage revisited: a further family study of manic-depressive illness. Arch. gen. Psychiat. 31, 665–672 (1974)
Goodwin, D. W., Schulsinger, F., Hermansen, L., Guze, S. B., Winokur, G.: Alcohol problems in adoptees raised apart from alcoholic biological parents. Arch. gen. Psychiat. 28, 238–243 (1973)
Goodwin, D. W., Schulsinger, F., Møller, N., Hermansen, L., Winokur, G., Guze, S. B.: Drinking problems in adopted and nonadopted sons of alcoholics. Arch. gen. Psychiat. 31, 164–169 (1974)
Gottesman, I. I., Shields, J.: Schizophrenia and genetics: a twin study vantage point. New York: Academic Press 1972
Hallgren, B.: Specific dyslexia (‘congenital word-blindness’): a clinical and genetic study. Acta psychiat. scand., Suppl. 65 (1950)
Hutchings, B.: Environmental and genetic factors in psychopathology and criminality. Unpublished M. Phil. thesis, University of London (1972)
Hutchings, B., Mednick, S. A.: Registered criminality in the adoptive and biological parents of registered male adoptees. In: Genetics, environment and psychopathology. Eds. S. A. Mednick et al. Amsterdam: North-Holland 1974
James, N. McI., Chapman, C. J.: A genetic study of bipolar affective disorder. Brit. J. Psychiat. 126, 449–456 (1975)
Kay, D. W. K.: The genetics of stuttering. In: The syndrome of stuttering. Clinics in developmental medicine No. 17. London: Heinemann 1964
Kety, S. S.: From rationalization to reason. Amer. J. Psychiat. 131, 957–963 (1974)
Mednick, S. A., Schulsinger, F., Higgins, J., Bell, B. (Eds.): Genetics, environment and psychopathology. Amsterdam: North-Holland 1974
Perris, C.: A study of bipolar (manic-depressive) and unipolar recurrent depressive psychoses. Acta psychiat. scand. 42, Suppl. 194 (1966)
Perris, C.: Abnormality on paternal and maternal sides: observations in bipolar (manic-depressive) and unipolar depressive psychoses. Brit. J. Psychiat. 118, 207–210 (1971)
Price, J.: The genetics of depressive behaviour. In: Recent developments in affective disorders. Eds. A. Coppen and A. Walk. Brit. J. Psychiat. Spec. Publn. No. 2. Ashford, Kent: Headley 1968
Rutter, M.: Why are London children so disturbed? Proc. roy. Soc. Med. 66, 1221–1225 (1973)
Rutter, M., Tizard, J., Whitmore, K.: Education, health and behaviour. London: Longman 1970
Schepank, H.: Erb- und Umweltfaktoren bei Neurosen. Tiefenpsychologische Untersuchungen an 50 Zwillingspaaren. Monographien aus dem Gesamtgebiete der Psychiatrie, Bd. 11. Berlin-Heidelberg-New York: Springer 1974
Schulsinger, F.: Psychopathy: Heredity and environment. In: Genetics and mental disorders. Ed. L. Erlenmeyer-Kimling. Int. J. ment. Hlth 1, 190–206 (1972)
Shapiro, R. W.: A twin study of “non-endogenous” depression. Acta Jutlandica 42, No. 2 (1970)
Shields, J.: Personality differences and neurotic traits in normal twin schoolchildren. Eugen. Rev. 45, 213–246 (1954)
Shields, J.: Concepts of heredity for schizophrenia. In: The origin of schizophrenia. Eds.: M. Bleuler and J. Angst. Bern: Huber 1971
Shields, J.: Polygenic influences in child psychiatry. In: Recent developments in child psychiatry. Eds. M. Rutter and L. Hersov. London: Blackwell Scientific Publications Ltd. (in press)
Shields, J., Gottesman, I. I. (Eds.): Man, mind and heredity: selected papers of Eliot Slater on psychiatry and genetics. Baltimore-London: Johns Hopkins Press 1971
Slater, E.: Zur Erbpathologie des manisch-depressiven Irreseins. Die Eltern und Kinder von Manisch-Depressiven. Z. ges. Neurol. Psychiat. 163, 1–47 (1938)
Slater, E., Shields, J.: Genetical aspects of anxiety. In: Studies of anxiety. Ed. M. H. Lader. Brit. J. Psychiat. Spec. Publn. No. 3. Ashford, Kent: Headley 1969
Stenstedt, Å.: Genetics of neurotic depression. Acta psychiat. scand. 42, 392–409 (1966)
Wender, P. H., Rosenthal, D., Kety, S. S., Schulsinger, F., Welner, J.: “Cross-fostering”: a research strategy for clarifying the role of genetic and experiential factors in the etiology of schizophrenia. Arch. gen. Psychiat. 30, 121–128 (1974)
Winokur, G.: Types of depressive illness. Brit. J. Psychiat. 120, 265–266 (1972)
Winokur, G., Tanna, V. L.: Possible role of X-linked dominant factor in manic depressive disease. Dis. nerv. Syst. 30, 89–94 (1969)
Zatz, M., Itskan, S. B., Sanger, R., Frota-Pessoa, O., Saldanha, P. H.: New linkage data for the X-linked types of muscular dystrophy and G6PD variants, colour blindness, and Xg blood groups. J. med. Genet. 11, 321–327 (1974)
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Paper read at the University Psychiatric Clinic, Burghölzli, Zürich, 30th April 1975.
I am grateful to Dr. J. S. Price and Dr. E. Zerbin-Rüdin for their assistance with the reanalysis of Slater's data, and to Dr. K. O. Christiansen for his data on male and female Danish criminal twins.
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Shields, J. Some recent developments in psychiatric genetics. Arch. Psychiat. Nervenkr. 220, 347–360 (1975). https://doi.org/10.1007/BF00342064
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DOI: https://doi.org/10.1007/BF00342064