Skip to main content
SpringerLink
Log in

Sequential computed tomographic imaging of a transplantable rabbit brain tumor

  • Experimental Work
  • Published:
Neuroradiology Aims and scope Submit manuscript

Summary

The accuracy of CT imaging in evaluating VX-2 tumor growth in the rabbit brain was assessed. CT scanning was performed in 5 outbred New Zealand white male rabbits before and at 4, 7, 9 and 13 (in 3 animals) days after surgical implantation of 3x105 viable VX-2 tumor cells in the frontoparietal lobes. The CT studies were correlated with gross pathology in each. The tumor was visualized with CT in all 5 rabbits by the 9th day post implantation when the tumor ranged in size from 4–6x3–4x2–3 mm. Between the 9th and 13th day, the tumor increased 6-fold in two rabbits and 12-fold in the third rabbit. CT is a useful technique to evaluate brain tumor growth in this model and should be valuable in documenting the efficacy of chemotherapy on tumor growth.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hasegawa H, Shapiro WR, Posner JB (1979) Chemotherapy of experimental metastatic brain tumors in female wistar rats. Cancer Res 39:2691–2697

    Google Scholar 

  2. Conley FK (1979) Development of a metastatic brain tumor model in mice. Cancer Res 39:1001–1007

    Google Scholar 

  3. Groothuis DR, Mikhael MA, Fischer JM, Pasternak JF, Fouts T, Begner DD, Vick NA (1981) Computed tompgraphy of virally induced canine brain tumors: A preliminary report. J Comput Assist Tomogr 5:538–543

    Google Scholar 

  4. Carson BS, Anderson JH, Grossman SA, Hilton J, White CL, Clovin OM, Clark AW, Grochow LB, Kahn A, Murray KJ (1982) Improved rabbit brain tumor model amenable to diagnostic radiographic procedures. Neurosurgery 2:603–608

    Google Scholar 

  5. Morgan DF, Silberman AW, Bubbers JE, Rand RW, Storm FK, Morton DL (1982) An experimental brain tumor model in rabbits. J Surg Oncol 20:218–220

    Google Scholar 

  6. Monnier N, Gangloff H (1961) Atlas for stereotaxic brain research on the conscious rabbit. Elsevier, New York

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA

    A. J. Kumar, A. E. Rosenbaum, T. J. Beck, H. S. Ahn & J. Anderson

  2. Department of Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA

    S. Hassenbusch

  3. Siemens Medical Systems, Inc., Alexandria, Virginia, USA

    R. Hadfield

  4. Neuroradiology Section Department of Radiology, Johns Hopkins Hospital, 600 N. Wolfe Street, 21205, Baltimore, MD, USA

    A. J. Kumar

Authors
  1. A. J. Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Hassenbusch
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. E. Rosenbaum
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. J. Beck
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. Hadfield
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H. S. Ahn
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J. Anderson
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This investigation was supported by PHS grants No. CA 32086 and CA 36920 awarded by the National Cancer Institute, DHHS

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kumar, A.J., Hassenbusch, S., Rosenbaum, A.E. et al. Sequential computed tomographic imaging of a transplantable rabbit brain tumor. Neuroradiology 28, 81–86 (1986). https://doi.org/10.1007/BF00341774

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00341774

Key wrods

Search

Navigation