Abstract
5-Fluorouracil (5-FU) remains the mainstay for systemic treatment of colorectal cancer. In view of the increasing interest in peri-operative administration of antineoplastic agents, we have investigated the effects of early postoperative 5-FU on the healing of intestinal anastomoses in the rat. Animals underwent resection and anastomosis of both ileum and colon and 5-FU (20 mg/kg body weight) was given, either intravenously or intraperitoneally, on the day of surgery and the two subsequent days. Healing was assessed three and seven days after operation. Administration of 5-FU led to a reduced white blood cell count. However, anastomotic strength was not significantly reduced at either time point and anastomotic hydroxyproline content was not significantly affected. We suggest that limited use of 5-FU during or immediately after operation does not necessarily affect early anastomotic healing in the intestine.
Résumé
Le 5-Fluorouracil (5-FU) demeure la base du traitement systémique du cancer colorectal. En raison de l'interêt croissan de l'administration péri-opératoire d'agents antinéoplasiques, nous avons étudié les effets du 5-FU post-opératoire précoce sur la cicatrisation des anastomoses intestinales chez le rat. Les animaux ont subi une résection et anastomose à la fois du colon et de l'iléon et le 5-FU (20 mg/kg de poids) était donné soit intraveineux soit intra-péritonéal le jour de la chirurgie et les 2 jours suivants. La cicatrisation était étudiée 3 et 7 jours après l'opération. L'administration de 5 FU conduit à une diminution du taux des globules blancs. Cependant, la force anatomotique n'était pas diminuée de façon significative à chaque contrôle et le contenu anastomotique d'hydroxyproline n'était pas significativement changé. Nous suggérons que l'usage limité de 5-FU durant ou immédiatement après l'opération n'affecte pas nécessairement la cicatrisation anastomotique précoce de l'intestin.
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de Waard, J.W.D., Wobbes, T. & Hendriks, T. Early post-operative 5-fluorouracil does not affect the healing of experimental intestinal anastomoses. Int J Colorect Dis 8, 175–178 (1993). https://doi.org/10.1007/BF00341194
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DOI: https://doi.org/10.1007/BF00341194