Summary
Combined Positron Emission Tomography (PET) and Proton Magnetic Resonance Imaging (MRI) study were performed in six patients with chronic supratentorial stroke to investigate whether remote hypometabolic regions revealed by PET showed any abnormality on MRI. Either regional oxygen consumption (n=4) or glucose utilization (n=2) were measured using PET and the 15O steady state 18FGD technique, respectively. Four patients, with deeply located brain lesions, showed a significant metabolic reduction in the overlying cerebral cortex. In the remaining two patients, affected by a large cortical infarct, there was a significant crossed cerebellar hypometabolism. The MRI weighted by the parameters spin density (ϱ), spin lattice (T1) and spin-spin (T2) relaxation times were obtained employing various sequences in the same subjects. In no patient did the MRI show any contrast modification in these hypometabolic remote regions, suggesting that subtle loss of tissue and/or biochemical change do not underlie the reduction in metabolic rate.
Similar content being viewed by others
References
Lenzi GL, Frackowiak RSJ, Jones T (1982) Cerebral oxygen metabolism and blood flow in human cerebral ischemic infarction. J Cerebr Blood Flow Metab 2:321–335
Rougemont D, Baron JC, Lebrun Grandiè P, Bousser MG, Soisson T, Comar D (1982) Débit sanguin cérébral et extraction d'oxygène dans les hémiplégies lacunaires: etude semiquantitative par l'oxygène-15 et la tomographie d'émission. Pathologie Biologie 30:295–302
Baron JC, D'Antona R, Pantano P, Serdaru M, Samson Y, Bousser MG (1986) Effects of thalamic stroke on energy metabolism of the cerebral cortex. Brain (in press)
Kuhl DE, Phelps ME, Kowell AP, Metter EJ, Selin C, Winter J (1980) Effects of stroke on local cerebral metabolism and perfusion: mapping by emission computed tomography of 18FDG and 13NH3. Ann Neurol 8:47–60
Phelps ME, Mazziotta JC, Kuhl DE, Nuwer M, Packwood J, Metter EJ, Engel J (1981) Tomographic mapping of human cerebral metabolism: visual stimulation and deprivation. Neurology 31:517–529
Heiss WD, Vyska K, Kloster G, Traupe H, Freundlieb C, Hoeck A, Feinendegen LE, Stoecklin G (1982) Demonstration of decreased functional activity of visual cortex by 11C-methylglucose and positron emission tomography. Neuroradiology 23:45–47
Baron JC, Bousser MG, Comar D, Castaigne P (1980/b) “Crossed cerebellar diaschisis” in human supratentorial brain infarction. Trans Am Neurol Assoc 105:459–461
Martin W, Raichle M (1983) Cerebellar blood flow and metabolism in cerebral hemisphere infarction. Ann Neurol 14: 168–176
Kushner M, Alavi A, Reivich M, Dann R, Burke A, Robinson G (1984) Contralateral cerebellar hypometabolism following cerebral insult: a positron emission tomography study. Ann Neurol 15:425–434
Pantano P, Baron JC, Samson Y, Bousser MG, De Rouesne C, Comar D (1986) Crossed cerebellar diaschisis: further studies. Brain 109:677–634
Jones T, Chesler DA, Ter Pogossian MM (1976) The continuous inhalation of oxygen 15 for assessing regional oxygen extraction in the brain of man. Br J Radiol 49, 339–343
Baron JC, Steinling M, Tanaka T, Cavalheiro E, Soussaline F, Collard P (1981c) Quantitative measurement of CBF, oxygen extraction fraction (OEF) and CMRO2 with the 15O continuous inhalation technique and positron emission tomography (PET): experimental evidence and normal values in man. J Cereb Blood Flow Metabol [Suppl] 1:5–6
Lammertsma AA, Jones T, Frackowiak RSJ, Lenzi GL (1981) A theoretical study of steady-state model for measuring regional cerebral blood flow and oxygen utilization using oxygen-15. J Comput Assist Tomogr 5:544–550
Lebrun-Grandié P, Baron JC, Soussaline F, Loc'h C, Sastre J, Bousser MG (1983) Coupling between regional blood flow and oxygen utilization in the normal human brain: a study with positron tomography and oxygen-15. Arch Neurol 40: 230–236
Pantano P, Baron JC, Lebrun-Grandié P, Duquesnoy N, Bousser MG, Comar D (1984) Regional cerebral blood flow and oxygen consumption in human aging. Stroke 15, 635–641
Steinling M, Baron JC, Mazière B, Lasjaunias P, Loc'h C, Cabanis EA, Guillon B (1985) Tomographic measurement of cerebral blood flow by the 68Ga-labelled microsphere and continuous C15O2 inhalation methods. Eur J Nucl Med 11:29–32
Reivich M, Kuhl D, Wolf A, Grenberg J, Phelps M, Ido T, Cassella V, Fowler J, Hoffman E, Alavi A, Som P, Sokoloff L (1979) The (18F) fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man. Circ Res 44: 127–137
Phelps ME, Huang SC, Hoffman EJ, Selin C, Sokoloff L, Kuhl DE (1979) Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18) 2-fluoro-2-deoxyD-glucose: validation of method. Ann Neurol 6:371–388
Soussaline F, Campagnolo R, Verrey B, Bendriem B, Bouvier A, Lecomte JL, Comar D (1984) Physical characterization of a time-of-flight positron emission tomography system for whole-body quantitative studies. J Nucl Med 25:P 46
Bradley WG, Waluch V, Zawadzki MB, Yadley R, Wycoff R (1984) Patchy, periventricular white matter lesions in the elderly. A common observation during NMR imaging. Non invasive medical imaging 1:35–41
Von Monakow C (1914) Die lokalisation im grosshirm und der abban der funktion durch kortikale herde. Wiesbaden, JF Bergmann, 26–34
Kanaya H, Endo H, Sugiyama T, Kuroda K (1983) “Crossed Cerebellar diaschisis”, in patients with putaminal hemorrage. J Cereb Blood Flow Metabol 3 [suppl]:27–28
Partain CL, James AE, Rollo FD, Price RR (1983) Nuclear magnetic resonance imaging. W. B. Saunders, Philadelphia
Pykett IL, Newhouse JH, Buonanno FS, Brady TJ, Goldman MR, Kistler JP, Pohost GM (1982) Principles of Nuclear Magnetic Resonance Imaging. Radiology 143:157–168
Brasch RC (1983) Work in progress: methods of contrast enhancement for NMR imaging and potential applications. Radiology 147:781–788
Crooks L, Hoenninger J, Arakawa M, Kaufman L, Mc Ree R, Watts J, Singer JH (1980) Tomography of hydrogen with nuclear magnetic resonance. Radiology 136:701–706
Crooks L (1985) The role of T1 and T2 in tissue identification. Society of Magnetic Resonance in Medicine, London 19–23 August, 1985
Pykett IL, Buonanno FS, Brady TJ, Kistler JP (1983) Techniques and approaches to proton NMR imaging of the head. Computerized Radiology 7:1–17
Bartkowski HK, Bederson J, Nishimura M, Brant-Zawadzki M, Moon R, Longar S, Pitts L (1985) Nuclear Magnetic Resonance (NMR) imaging and spectroscopy in experimental brain edema in the rat. Cerebral blood flow and metabolism measurement. Springer-Verlag, Berlin Heidelberg, pp 540–545
Buonanno FS, Pykett IL, Brady TJ, Vielma J, Burt CT, Goldman MR, Hinshaw WS, Pohost GM, Kistler JP (1983) Proton NMR imaging in experimental ischemic infarction. Stroke 14: 178–184
Kato H, Kogure K, Ohtomo H, Tobita M, Matsui S, Yamamoto E, Kohno H (1985) Correlations between proton nuclear magnetic resonance imaging and retrospective histochemical images in experimental cerebral infarction. J Cerebral Blood Flow Metabolism 5:267–274
Runge VM, Stewart RG, Clanton JA, Jones MM, Lukehart CM, Partain CL, James AE (1983) Work in progress: potential oral and intravenous paramagnetic NMR contrast agent. Radiology 147:789–791
Pykett IL, Rosen BR (1983) Nuclear Magnetic Resonance: in vivo proton chemical shift imaging. Radiology 149:197–201
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pappata, S., Tran Dinh, S., Baron, J.C. et al. Remote metabolic effects of cerebrovascular lesions: magnetic resonance and positron tomography imaging. Neuroradiology 29, 1–6 (1987). https://doi.org/10.1007/BF00341027
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00341027