MR imaging of the various stages of normal myelination during the first year of life

Summary

The normal process of myelination of the brain mainly occurs during the first year of life. This process as known from histology can be visualized by MRI. Because of the very long T1 and T2 of immature brain tissue it is necessary to use adjusted pulse sequences with a long TR in order to obtain sufficient tissue contrast. With long TR SE images five stages can be recognized in the process of normal myelination and brain maturation. During the first month of life long TR short TE SE images show what are believed to be myelinated structures by correlation with published histological studies with a high signal intensity, unmyelinated white matter with a low signal intensity and gray matter with an intermediate signal intensity. The signal intensity of unmyelinated and myelinated white matter is reversed on long TR long TE SE images. In the course of a few weeks the signal intensity of unmyelinated white matter becomes high and the signal intensity of myelinated white matter becomes low also on long TR short TE SE images. These changes are believed to be caused by a loss of water and a change in chemical composition of brain tissue just prior to the onset of a wave of myelination. With progression of myelination the signal intensity of white matter changes from high to intermediate to low. These changes result in stages of isointensity, first in the central parts of the brain, later in the peripheral parts. At the end of the first year the adult contrast pattern is reached in all parts of the brain. IR images are also able to depict the progress of myelination, but appear to be less sensitive to subtle changes in the degree of myelination. The precise normal values for the five stages depend on the magnetic field strength and the pulse sequences used.

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References

  1. 1.

    Keene LMR, Hewer EE (1931) Some observations on myelination in the human nervous system. J Anat 6:1–13

    Google Scholar 

  2. 2.

    Yakovlev PI, Lecours AR (1967) The myelogenetic cycles of regional maturation in the brain. In: Minkowski A (ed) Regional development of the brain in early life. Blackwell, Oxford, pp 3–70

    Google Scholar 

  3. 3.

    Rorke LB, Riggs HE, Showers MJC, Cabrera CV, Cohn M (1969) Myelination of the brain of the newborn. Lippincott, Philadelphia, pp 11–15 and 30–63

    Google Scholar 

  4. 4.

    Davison AN, Peters A (1970) Myelination. Thomas, Springfield (IL), pp 162–182

    Google Scholar 

  5. 5.

    Gilles FH (1976) Myelination in the neonatal brain. Hum Pathol 7:244–248

    Google Scholar 

  6. 6.

    Gilles FH, Shankle W, Dooling EC (1983) Myelinated tracts: growth patterns. In: Gilles, FH, Leviton A, Dooling EC (eds) The developing human brain. Growth and epidemiologic neuropathology. Wright, Boston, pp 117–183

    Google Scholar 

  7. 7.

    Brody BA, Kinney HC, Kloman AS, Gilles FH (1987) Sequence of central nervous system myelination in human infancy. I. An autopsy study of myelination. J Neuropathol Exp Neurol 46:283–301

    Google Scholar 

  8. 8.

    Kinney HC, Brody BA, Kloman AS, Gilles FH (1988) Sequence of central nervous system myelination in human infancy. II. Patterns of myelination in autopsied infants. J Neuropathol Exp Neurol 47:217–234

    Google Scholar 

  9. 9.

    Johnson MA, Pennock JM, Bydder GM, Steiner RE, Thomas DJ, Hayward R, Bryant DRT, Payne JA, Levene MI, Whitelaw A, Dubowitz LMS, Dubowitz V (1983) Clinical NMR imaging of the brain in children: normal and neurologic disease. AJR 141:1005–1018

    Google Scholar 

  10. 10.

    Holland BA, Haas DK, Norman D, Brant-Zawadzki M, Newton TH (1986) MRI of normal brain maturation. AJNR 7: 201–208

    Google Scholar 

  11. 11.

    Lee BCP, Lipper E, Nass R, Ehrlich ME, de Ciccio-Bloom E, Auld PAM (1986) MRI of the central nervous system in neonates and young children. AJNR 7:605–616

    Google Scholar 

  12. 12.

    Valk J (1987) Myelination. In: Valk J (ed) MRI of the brain, head, neck and spine. Nijhoff, Dordrecht, pp 362–397

    Google Scholar 

  13. 13.

    Mintz MC, Grossman RI, Isaacson G, Thickman DI, Kundel H, Joseph P, DeSimone D (1987) MR imaging of fetal brain. J Comput Assist Tomogr 11:120–123

    Google Scholar 

  14. 14.

    McArdle CB, Richardson CJ, Nicholas DA, Mirfakhraee M, Hayden CK, Amparo EG (1987) Development features of the neonatal brain: MR imaging, part I, gray-white matter differentiation and myelination. Radiology 162:223–229

    Google Scholar 

  15. 15.

    McArdle CB, Richardson CJ, Nicholas DA, Mirfakhraee M, Hayden CK, Amparo EG (1987) Developmental features of the neonatal brain: MR imaging, part II, ventricular size and extracerebral space. Radiology 162:230–234

    Google Scholar 

  16. 16.

    Dietrich RB, Bradley WG, Zaragoza EJ, Otto RJ, Taira RK, Wilson GH, Kangarloo H (1988) MR evaluation of early myelination patterns in normal and developmentally delayed infants AJNR 9:69–76

    Google Scholar 

  17. 17.

    Barkovich AJ, Kjos BO, Jackson DE, Norman D (1988) Normal maturation of the neonatal and infant brain: MR imaging at 1,5 T. Radiology 166:173–180

    Google Scholar 

  18. 18.

    Martin E, Kikinis R, Zuerrer M, Boesch Ch, Briner J, Kewitz G, Kaelin P (1988) Developmental stages of human brain: an MR study. J Comput Assist Tomogr 12:917–922

    Google Scholar 

  19. 19.

    Valk J, van der Knaap MS (1989) MR of myelin, myelination and myelin disorders. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  20. 20.

    Masumura M (1987) Proton relaxation time of immature brain, II. In vivo measurements of proton relaxation time (T1 and T2) in pediatric brain by MRI. Childs Nerv Syst 3:6–11

    Google Scholar 

  21. 21.

    Baierl P, Förster C, Fendel H, Naegele M, Fink U, Kenn W (1988) Magnetic resonance imaging of normal and pathological white matter maturation. Pediatr Radiol 18:183–189

    Google Scholar 

  22. 22.

    Uzman LL, Rumley MK (1958) Changes in the composition of the developing mouse brain during early myelination. J Neurochem 3:170–184

    Google Scholar 

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van der Knaap, M.S., Valk, J. MR imaging of the various stages of normal myelination during the first year of life. Neuroradiology 31, 459–470 (1990). https://doi.org/10.1007/BF00340123

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Key words

  • Myelination
  • MR imaging
  • Scheme of normal values