Summary
Review of the literature reveals no previous clinical, roentgenographic, and pathological correlation of a brain as severely affected by cytomegalic inclusion disease as the present case. The case demonstrates: 1. the infrequently described occurrence of transplacental infection early in gestation; 2. striking roentgen evidence of CNS devastation and calcification; 3. correlation of the temporal occurrence of the mother's infection (manifested by “cold sores” or “fever blisters”) with the stage of arrest of fetal brain development.
Résumé
La revue de la littérature ne révèle aucune description clinique, radiologique et anatomo-pathologique de cerveau aussi sévèrement touché par la maladie des inclusions cytomégaliques. Le cas démontre: 1. l'infection transplacentaire précoce, 2. la nette mise en évidence radiologique de la détérioration et de calcification du système nerveux central, 3. la corrélation entre l'apparition des signes d'infection chez la mère (sueurs froides ou poussées fébriles) et l'arrêt du développement du cerveau du foetus.
Zusammenfassung
Es wird über die klinische Symptomatik, die röntgenologisch nachweisbaren Veränderungen und die pathologisch-anatomische Korrelation eines Neugeborenen berichtet, bei dem ein Cytomegali-Syndrom vorhanden war. Bei der Mutter bestand während des 4. Schwangerschaftsmonat eine fieberhafte Erkrankung, bei der es sich möglicherweise um eine Virusinfektion gehandelt hat.
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McCabe, M.J., Pribram, H.F.W. & O'Loughlin, B.J. Cytomegalic inclusion disease; a clinico-pathological correlation. Neuroradiology 3, 177–181 (1972). https://doi.org/10.1007/BF00339950
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DOI: https://doi.org/10.1007/BF00339950