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Terminal degeneration in the lateral geniculate body of the monkey; An electron-microscope study

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Summary

  1. 1.

    The degeneration of optic terminals in the lateral geniculate body (LGB) has been studied in 16 monkeys after enucleation of one eye. In contrast to the results of our previous studies with the ligth-microscope, electronmicroscopical studies of normal and degenerated LGB now reveal complex synaptic structures, many of them arranged in synaptic islands.

  2. 2.

    The presence of bulbous enlargement of synapses, the functional portion of terminals, occuring during the process of degeneration, previously reported, is confirmed. They are considered to be due to a marked fibrillisation of the cytoplasm.

  3. 3.

    Other clear signs of synaptic degeneration besides the enlargement are the disappearance of synaptic vesicles and an irregular disintegration of the intersynaptic connecting (“cementing”) substance.

  4. 4.

    Reactive neuroglia produce a complex of enveloped synaptic and myelin débris, penetrating normal neighbouring layers. Great care must be taken in interpreting late stages of degeneration.

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Authors and Affiliations

  1. Institut für Histologie und experimentelle Neuroanatomie, Göttingen

    P. Glees, K. Meller & J. Eschner

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  1. P. Glees
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  2. K. Meller
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  3. J. Eschner
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We would like to express our thanks to the Deutsche Forschungsgemeinschaft for their generous support (Gl 28/10).

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Glees, P., Meller, K. & Eschner, J. Terminal degeneration in the lateral geniculate body of the monkey; An electron-microscope study. Zeitschrift für Zellforschung 71, 29–40 (1966). https://doi.org/10.1007/BF00339828

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  • DOI: https://doi.org/10.1007/BF00339828

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