Summary
Transplantable malignant tumors of mice and rats have been irradiated continuously for several days by means of embedded glass beads containing Sr90-Y90. Concomitant enlargement of tumor cell nuclei occurs in areas where mitosis is inhibited, i.e. associated with doses of 1200–2000 rads per day and above. Some enlarged cells survive at least a week in areas where the dose rate is much higher than this. Intense incorporation of thymidine into enlarged cells can be seen at least a week after beginning irradiation.
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Dedicated to Professor Friedrich Wassermann with admiration and affection on the occasion of his eightieth birthday.
Work supported by the U.S. Atomic Energy Commission.
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Brues, A.M., Stroud, A.N. Formation of giant nuclei in continuously irradiated tumors. Z.Zellforsch 64, 52–62 (1964). https://doi.org/10.1007/BF00339185
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DOI: https://doi.org/10.1007/BF00339185