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Nucleoside auxotrophy in Drosophila: An autosomal locus yielding mutants supplementable by purine and pyrimidine ribonucleosides

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Summary

Two allelic auxotrophic mutants at a locus close to the bw locus (2–104.5) of Drosophila melanogaster are described. The mutants respond to dietary ribonucleosides (uridine, cytidine, adenosine, guanosine and inosine) but less well to bases or pyrimidine precursors. This phenotype is unique to these mutants.

We suggest that the mutants are defective in phosphoribosyl pyrophosphate biosynthesis.

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Author notes

  1. Fardos N. M. Naguib

    Present address: C.N.R.S. Centre de Biochemie et de Biologie Moleculaire, 31, Chemin Joseph-Aiguier, 13-Marseille (9e), France

Authors and Affiliations

  1. Department of Genetics, University of Alberta, T6G 2E9, Edmonton, Alberta, Canada

    Fardos N. M. Naguib & David Nash

Authors
  1. Fardos N. M. Naguib
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  2. David Nash
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Communicated by W. Gehring

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Naguib, F.N.M., Nash, D. Nucleoside auxotrophy in Drosophila: An autosomal locus yielding mutants supplementable by purine and pyrimidine ribonucleosides. Molec. gen. Genet. 147, 13–21 (1976). https://doi.org/10.1007/BF00337930

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  • DOI: https://doi.org/10.1007/BF00337930

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