Abstract
We assume that between lateral geniculate and visual cortical cells there exist labile synapses that modify themselves in a new fashion called threshold passive modification and in addition, non-labile synapses that contain permanent information. In the theory which results there is an increase in the specificity of response of a cortical cell when it is exposed to stimuli due to normal patterned visual experience. Non-patterned input, such as might be expected when an animal is dark-reared or raised with eyelids sutured, results in a loss of specificity, with details depending on whether noise to labile and non-labile junctions is correlated. Specificity can sometimes be regained, however, with a return of input due to patterned vision. We propose that this provides a possible explanation of experimental results obtained by Imbert and Buisseret (1975); Blakemore and Van Sluyters (1975); Buisseret and Imbert (1976); and Frégnac and Imbert (1977, 1978).
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References
Anderson, J.A.: Two models for memory organization using interacting traces. Math. Biosci. 8, 137–160 (1970)
Anderson, J.A.: A simple neural network generating an interactive memory. Math. Biosci. 14, 197–220 (1972)
Anderson, J.A., Silverstein, J.W., Ritz, S.A., Jones, R.S.: Distinctive features, categorical perception, and probability learning. Some applications of a neural model. Psychoanal. Rev. 84, 413–451 (1977)
Anderson, J.A., Cooper, L.N.: Les modeles mathematiques de l'organization biologique de la memoire. Plurisci. 168–175 (1978)
Batini, C., Buisseret, P.: Sensory peripheral pathway from extrinsic eye muscles. Arch. Ital. Biol. 112, 18–32 (1974)
Bienenstock, E., Frégnac, Y.: Stability of response of single cells in kittens visual cortex. (to be published)
Blakemore, C., Cooper, G.F.: Development of the brain depends on the visual environment. Nature 228, 477–478 (1970)
Blakemore, C., Mitchell, D.E.: Environmental modification of the visual cortex and the neural basis of learning and memory. Nature 241, 467–468 (1973)
Blakemore, C., Van Sluyters, R.C.: Reversal of the Physiological effects of monocular deprivation in kittens. Further evidence for a sensitive period. J. Physiol. (London) 237, 195–216 (1974)
Blakemore, C., Van Sluyters, R.C.: Innate and environmental factors in the development of the kitten's visual cortex. J. Physiol. (London) 248, 663–716 (1975)
Buisseret, P., Imbert, M.: Visual cortical cells. Their developmental properties in normal and dark reared kittens. J. Physiol. (London) 255, 511–525 (1976)
Buisseret, P., Gary-Bobo, E., Imbert, M.: Ocular motility and recovery of orientational properties of visual cortical neurons in dark-reared kittens. Nature 272, 816–817 (1978)
Cooper, L.N.: A Possible organization of animal memory and learning. In: Proceedings of the Nobel Symposium on Collective Properties of Physical Systems. Lundquist, B., Lundquist, S., eds. London, New York 24, 252–264 (1973)
Frégnac, Y., Imbert, M.: Cinetique de developement des cellules du cortex visuel. J. Physiol. (Paris) 6, T.73 (1977)
Frégnac, Y., Imbert, M.: Early development of visual cortical cells in normal and dark-reared kittens. Relationship between orientation selectivity and ocular dominance. J. Physiol. (London) 278, 27–44 (1978)
Frégnac, Y.: Cinetique de development du cortex visuel primaire chez le chat. Effets de la privation visuelle binoculaire et modele de maturation de la selective a l'orientation. Doctoral thesis, Université René Descartes (1978)
Hebb, D.O.: The organization of behavior. New York. Wiley 1949
Henry, G.H., Dreher, B., Bishop, P.O.: Orientation specificity of cells in cat striate cortex. J. Neurophysiol. 137, 1394–1409 (1974)
Herz, A., Creutzfeldt, O., Fuster, J.: Statistische Eigenschaften der Neuronaktivität im ascendierenden visuellen System. Kybernetik 2, 61–71 (1964)
Hirsch, H.V.B., Spinelli, D.N.: Modification of the distribution of receptive field orientation in cats by selective visual exposure during development. Exp. Brain Res. 12, 509–527 (1971)
Hubel, D.H., Wiesel, T.N.: Receptive fields of single neurons in the cat striate cortex. J. Physiol. (London) 148, 574–591 (1959)
Hubel, D.H., Wiesel, T.N.: Receptive fields binocular interaction and functional architecture in the cat's visual cortex. J. Physiol. (London) 160, 106–154 (1962)
Imbert, M., Buisseret, P.: Receptive field characteristics and plastic properties of visual cortical cells in kittens reared with or without visual experience. Exp. Brain Res. 22, 2–36 (1975)
Kaldel, E.R.: Cellular basis of behavior. San Francisco: Freeman 1976
Kohonen, T.: Correlation matrix memories. IEEE Trans. Comput. C-21, 353–359 (1972)
Kohonen, T.: Associative memory — a system-theoretical approach. Berlin, Heidelberg, New York: Springer 1977
Kohonen, T., Oja, E.: Fast adaptive formation of orthogonalizing filters and associative memory in recurrent networks of neuron like elements. Biol. Cybernetics 21, 85–95 (1976)
Kohonen, T., Lethiö, P., Rovamo, J., Hyvärinen, J., Bry, K., Vainio, L.: A principle of neural associative memory. Neuroscience 2, 1065–1076 (1977)
Movshon, J.A.: Reversal of the physiological effects of monocular deprivation in the kittens visual cortex. J. Physiol. (London) 261, 125–174 (1976)
Nass, M., Cooper, L.N.: A theory for the development of feature detecting cells in visual cortex. Biol. Cybernetics 19, 1–18 (1975)
Perez, R., Glass, L., Shlaer, R.J.: Development of specificity in the cat visual cortex. J. Math. Biol. 1, 275–288 (1975)
Pettigrew, J.D., Freeman, R.D.: Visual experience without lines. Effects on developing cortical neurons. Science 182, 599–601 (1973)
Pettgrew, J.D.: The effect of visual experience on the development of stimulus specificity by kitten cortical neurons. J. Physiol. 237, 49–74 (1974)
Spear, P.D., Tong, L., Langsetmo, A.: Striate cortex neurons of binocularly deprived kittens respond to visual stimuli through the closed eyelids. Brain Res. 155, 141–146 (1978)
von der Malsburg, C.: Self-organization of orientation sensitive cells in the striate cortex. Kybernetic 14, 85–100 (1973)
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This work was supported in part by a grant from the Ittleson Foundation, Inc.
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Cooper, L.N., Liberman, F. & Oja, E. A theory for the acquisition and loss of neuron specificity in visual cortex. Biol. Cybernetics 33, 9–28 (1979). https://doi.org/10.1007/BF00337414
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DOI: https://doi.org/10.1007/BF00337414