Abstract
Some tumors of hormonal organs are clinically active, while others are not. The “silent” tumors may be discovered by accident or because of effects due to their increase in size. From a simple steady state analysis of hormonal feedback systems follows that hormonal cell multiplication does not significantly influence the systems steady state behaviour (hence the clinical silence). —Exceptions to this rule occur in three situations: when the gain of the system is low; when the growth concerns cells with isolated sensor or reference functions; or because of the growth of autonomous cells. In many biological systems the dangerous situation of clamping to low levels upon sensor cell multiplication has been prevented by lumping, such as the combination of sensor and comparator functions into sensor-comparator cells.
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References
DiStefano III, J.J., Stubberud, A. R., Williams, I.J.: Feedback and control systems. New York: Schaum 1967
Labhart, A.: Clinical endocrinology (cf. p. 118, 342, 820, 911, 938). Berlin, Heidelberg, New York: Springer 1974
Mitchell, D., Snellen, J.WW., Atkins, A. R.: Thermoregulation during fever: change of set-point or change of gain. Pflügers Arch. 321, 293–302 (1970)
Williams, R. H.: Ed. Textbook of endocrinology. 5th ed., Philadelphia, London, Toronto: Saunders 1974
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Verveen, A.A. Silent endocrine tumors. Biol. Cybernetics 31, 49–54 (1978). https://doi.org/10.1007/BF00337370
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DOI: https://doi.org/10.1007/BF00337370