Abstract
We propose a mathematical model of the human hypothalamus-anterior pituitary-thyroid system regulating basal metabolism, and practice computer simulation concerning primary thyropathy such as Graves' disease, hypothyroidism, T 4-toxicosis and T 3-toxicosis by use of this model. In order to throw light on properties of the system, indicial responses of the hormones, T 4, T 3, rT 3, and TSH, and the function of the thyroid gland are computed. Medical treatments for Graves' disease and for hypothyroidism are simulated with a view to enhancing clinical significance. Performance of the simulation leads to an interesting result that when the convertion rate of blood T 4 to blood T 3 increases, explicit T 3-toxicosis occurs, although the function of the thyroid gland is normal.
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Hatakeyama, T., Yagi, H. Computer simulation for hormones related to primary thyropathy. Biol. Cybern. 52, 259–266 (1985). https://doi.org/10.1007/BF00336982
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DOI: https://doi.org/10.1007/BF00336982