Summary
Tabby male mice (X Ta Y) were irradiated with 600 R of X-rays and mated in the post-sterile period to untreated C 3 H females (X + X +). The incidence of XO females after X-irradiation of the spermatogonia was not significantly different from the rate found in the control series. The phenotype of these exceptional females indicates that they are patroclinous XO females. Chromosome counts performed on bone-marrow show that most of the cells have 39 chromosomes as compared to 40 found in the controls.
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References
Cattanach, B. M.: A chemically-induced variegated-type position effect in the mouse. Z. Vererbungsl. 92, 165–182 (1961).
—: XO mice. Genet. Res. 3, 487–490 (1962).
Evans, E. P., G. Breckon, and C. E. Ford: An air-drying method for meiotic preparations from mammalian testes. Cytogenetics 3, 289–294 (1964).
Falconer, D. S.: A totally sex-linked gene in the house mouse. Nature (Lond.) 169, 664–665 (1952).
Russell, L. B.: The genetics of mammalian sex-chromosomes. Science 133, 1795–1803 (1961).
—, and C. L. Saylors: Spontaneous and induced abnormal sex-chromosome number in the mouse. Genetics 46, 894 (1961).
Russell, L. B., and C. L. Saylors: The relative sensitivity of various germcell stages of the mouse to radiation-induced nondisjunction, chromosome losses and deficiencies. In: Repair from Genetic Radiation damage and differential radiosensitivity in germ-cells, p. 313–340 (F. H. Sobels, ed.). Oxford 1963.
Russell, W. L., L. B. Russell, and J. S. Grower: Exceptional inheritance of a sex-linked gene in the mouse explained on the basis that the X/O sex-chromosome constitution is female. Proc. nat. Acad. Sci. (Wash.) 45, 554–560 (1959).
Welshons, W. J., and L. B. Russell: The Y-chromosome as the bearer of male determining factors in the mouse. Proc. nat. Acad. Sci. (Wash.) 45, 560–566 (1959).
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Léonard, A., Schröder, J.H. Incidence of XO mice after X-irradiation of spermatogonia. Molec. Gen. Genetics 101, 116–119 (1968). https://doi.org/10.1007/BF00336576
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DOI: https://doi.org/10.1007/BF00336576