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Cytological, radioautographic and ultrastructural studies on the effect of 5-fluorouracil on rat liver

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Summary

Young rats were given two doses of 50 mg 5-fluorouracil with a 22-hour interval. One hour after the second dose they were given either cytidine-3H or leucine-3H and killed three hours later. Radioautographs of the livers revealed a decrease in RNA labelling, whereas the protein labelling was essentially uninfluenced. The liver cells exhibited an increase in nucleolar volume. Electron microscopy revealed changes in the ultrastructure of the liver cell nucleoli, while other parts of the cells were essentially unaltered.

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Authors and Affiliations

  1. Department of Pathology, University of Uppsala, Sweden

    Unne Steneram

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  1. Unne Steneram
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Additional information

The investigation was supported by a research grant (project No Y 515) from the Swedish Medical Research Council and Riksföreningen mot Cancer.

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Steneram, U. Cytological, radioautographic and ultrastructural studies on the effect of 5-fluorouracil on rat liver. Zeitschrift für Zellforschung 71, 207–216 (1966). https://doi.org/10.1007/BF00335747

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  • DOI: https://doi.org/10.1007/BF00335747

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