Abstract
The levels of alpha-1 microglobulin (α 1m) and beta-2 microglobulin (β 2m) in serum were estimated in 77 bone marrow transplant recipients. In comparison to pretransplant levels, the highest levels of α 1m and β 2m were found during impairment of renal function, i.e., during cyclosporin-induced nephrotoxicity and during treatment with other nephrotoxic drugs (P<0.001). The α 1m levels were less elevated during infections and acute graft-versus-host disease (P<0.01), while β 2m levels were markedly elevated during the same conditions (P<0.001). The linear correlations between serum creatinine and α 1m and creatinine and β 2m were r=0.7 and 0.8, respectively (P<0.001). The overall correlation between α 1m and β 2m was 0.4 (P<0.001). It is concluded that α 1m might be a complement to serum creatinine levels in monitoring renal function after bone marrow transplantation.
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Duraj, F.F., Bäckman, L., Dati, F. et al. Serum levels of alpha-1 microglobulin and beta-2 microglobulin in bone marrow transplant recipients treated with cyclosporin A. Transplant Int 4, 146–150 (1991). https://doi.org/10.1007/BF00335335
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DOI: https://doi.org/10.1007/BF00335335