Abstract
We report a previously unrecognized complication of totally implanted subcutaneous ports. A patient with a totally implantable central venous device developed a septic syndrome. Blood and injection-reservoir cultures grew Staphylococcus aureus. There was no evidence of endocarditis. The port was removed but acute oliguric renal failure developed. A percutaneous renal biopsy showed acute diffuse proliferative glomerulonephritis. There was no extracapillary crescent. On immunofluorescence study, capillary wall granular deposits stained brightly for IgG and C3. These findings were thought to be consistent with infection-associated immune-complex glomerulonephritis.
References
Arze RS, Rashid H, Morley R, Ward MK, Kerr DNS (1983) Shunt nephritis: report of two cases and review of the literature. Clin Nephrol 19:48–53
Beaufils M, Morel-Maroger L, Sraer JD, Kanfer A, Kourilsky O, Richet G (1976) Acute renal failure of glomerular origin during visceral abcesses. N Engl J Med 295:185–189
Case report of the Massachusetts General Hospital (1987) Weekly clinicopathological exercises. Case 26-1987: a 67-year-old man with progressive renal failure. N Engl J Med 316:1642–1651
Fisbach M, Tarral E, Marcellin L, Boillettot A, Geisert J (1986) Insuffisance rénale chronique après pose d'un cathéter veineux central. Ann Pédiatr 33:197–199
Groeger JS, Lucas AB, Thaler HT, Friedlander-Klar H, Brown AE, Kiehn TE, Armstrong D (1993) Infectious morbidity associated with long-term use of venous access devices in patients with cancer. Ann Intern Med 119:1168–1174
Gyves JW, Ensminger WD, Niederhuber JE, Dent T, Walker S, Gilbertson S, Cozzi E, Saran P (1984) A totally implanted injection port system for blood sampling and chemotherapy administration. JAMA 251:2538–2541
Lokich JJ, Bothe A, Benotti P, Moore C (1985) Complications and management of implanted venous access catheters. J Clin Oncol 3:710–717
Nelson BE, Mayer AR, Tseng PC, Schwartz PE (1994) Experience with the intravenous implanted port in patients with gynecologic malignancies. Gynecol Oncol 53:98–102
Neugarten J, Baldwin DS (1984) Glomerulonephritis in bacterial endocarditis. Am J Med 77:297–304
Pegues D, Axelrod P, McClarren C, et al (1992) Comparison of infections in Hickman and implanted port catheters in adult solid tumor patients. J Surg Oncol 49:156–162
Severien C, Nelson JD (1991) Frequency of infections associated with implanted systems versus cuffed, tunneled silastic venous catheters in patients with acute leukemia. Am J Dis Child 145:1433–1438
Sinassamy P, Landthaler G, Vasmant D (1986) Insuffisance rénale aiguë d'origine glomérulaire et infection à staphylocoque. A propos de deux observations pédiatriques. Ann Pédiatr 33:191–194
Wesenberg F, Flaatten H, Janssen CW (1993) Central venous catheter with subcutaneous injection port (port-a-Cath): 8 years clinical follow up with children. Pediatr Hematol Oncol 10:233–239
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pulik, M., Lionnet, F., Genet, P. et al. Immune-complex glomerulonephritis associated with Staphylococcus aureus infection of a totally implantable venous device. Support Care Cancer 3, 324–326 (1995). https://doi.org/10.1007/BF00335312
Issue Date:
DOI: https://doi.org/10.1007/BF00335312