Summary
The observation of macrophages which can act either as scavenger cells or as nurse cells leads to the conclusion that the factors responsible for the release of young erythrocytes or for the destruction of old erythrocytes lie with the red blood cells themselves rather than with the macrophages.
An electron microscope study of the various stages of erythropoiesis and erythrophagocytosis, considered in the light of certain physical-chemical concepts, suggests the possibility that the various patterns of interaction of macrophages with erythroblasts, immature and mature erythrocytes, are due to variations in the zeta potentials of the blood cells.
Résumé
L'observation de macrophages assumant en même temps un rôle de cellules nourricières donne à conclure que les facteurs responsables de la libération des érythrocytes ou de la phagocytose des globules rouges se trouvent au niveau des globules rouges euxmêmes.
L'étude au microscope électronique des phases de l'érythropoïèse et de l'érythrophagocytose jointe à certaines données de physicochimie font intervenir les variations du potentiel zêta de la membrane des globules rouges comme origine des variations de comportement des érythroblastes et des globules rouges immatures et matures vis-à-vis des cellules macrophages.
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This work was supported by Grant No 4237 of the Swiss National Foundation for Scientific Research.
We wish to thank Mrs. M. Sidler-Ansermet for her invaluable technical assistance.
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Pictet, R., Orci, L., Forssmann, W.G. et al. An electron microscope study of the perfusion-fixed spleen. Z. Zellforsch. 96, 400–417 (1969). https://doi.org/10.1007/BF00335216
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DOI: https://doi.org/10.1007/BF00335216