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The toxicity of the non-ionic watersoluble contrast medium metrizamide (Amipaque) in selective vertebral angiography

An experimental study in rabbits

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Summary

Selective left vertebral angiography was carried out in 21 rabbits comparing the toxic effects of meglumine iothalamate (Conray meglumine), meglumine metrizoate (Isopaque Cerebral) and metrizamide (Amipaque). The iodine concentration for all 3 media was 280 mg/ml. General convulsions were seen in many of the animals with all 3 media. The convulsions occurred at higher doses and were milder with metrizamide than with the 2 other contrast agents. Bradycardia was also seen with all 3 media and there was no statistical significant difference between them in this respect. The mortality was approximately 50% with both meglumine iothalamate and meglumine metrizoate, while no animals died following angiography with metrizamide.

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References

  1. Acta radiol Suppl. 355

  2. Almén, T., Wiedman, M.P.: Application of monomers and polymers to the external surface of the vasculature. Effects on microcirculation in the bat wing. Invest. Radiol. 3, 408 (1968)

    Google Scholar 

  3. Amundsen, P., Dietrichson, P., Enge, I., et al.: Cerebral angiography by catheterization-complications and side effects. Acta radiol. 1, 164 (1963)

    Google Scholar 

  4. Bjørk, L.: The osmotic effects of urografin 76 per cent and Isopaque 60 per cent in angiography. Amer. J. Roentgenol. 98, 922 (1966)

    Google Scholar 

  5. Cronqvist, S., Efsing, H.O., Palacios, E.: Embolic complications in cerebral angiography with the catheter technique. Acta radiol. diagn. 10, 97 (1970)

    Google Scholar 

  6. Fischer, H.W., Cornell, S.H.: The toxicity of the sodium and methylglucamine salts of diatrizoate, iothalamate, and metrizoate. Radiology 85, 1013 (1965)

    Google Scholar 

  7. Golman, K., Salvesen, S.: Personal communication 1975

  8. Gonsette, R.E.: Experimental study of the biological tolerance of the central nervous system to a new water soluble non-ionic contrast medium (metrizamide). Acta radiol. suppl. 335, 25 (1973)

    Google Scholar 

  9. Greitz, T., Törnell, G.: Bradycardial reactions during cerebral angiography. A comparison of isopaque sodium, isopaque B, hypopaque and urografin. Acta radiol. suppl. 270, 75 (1967)

    Google Scholar 

  10. Hilal, S.K.: Hemodynamic changes associated with the intraarterial injection of contrast media. New toxicity tests and a new experimental contrast medium. Radiology 86, 615 (1966)

    Google Scholar 

  11. Holtermann, H.: Metrizamide. Introduction. Acta radiol. suppl. 335, 1 (1973)

    Google Scholar 

  12. Lindgren, P., Saltzman, G., Törnell, G.: Vascular effects of metrizoate compounds, Isopaque Na and Isopaque Na/Ca/Mg. Acta radiol. suppl. 270, 44 (1967)

    Google Scholar 

  13. Lundervold, A., Engeset, A.: Polygraphic recordings of EEG, ECG, and blood pressure during cerebral angiography with Isopaque B. Acta radiol. suppl. 270, 87 (1967)

    Google Scholar 

  14. Lundervold, A., Engeset, A.: Recordings of EEG, ECG, EMG and intra-arterial blood pressure during cerebral angiography. Acta radiol. suppl. 270, 198 (1967)

    Google Scholar 

  15. Lundervold, A., Ongre, A.: Polygraphic recordings in cerebral angiography with meglumine metrizoate and meglumine iothalamate. Farmakoterapi 24, 3 (1968)

    Google Scholar 

  16. Olin, T., Redman, H.C.: Experimental evaluation of contrast media in the vertebral circulation. Acta radiol. 270, 216 (1967)

    Google Scholar 

  17. Pollock, J.A.: Personal communication 1973, cit. Howieson, J.: Complications of Cerebral Angiography, pp. 1034–1046 in Newton, T.H. and Potts, D.G.: Radiology of the Skull and Brain. Angiography.

  18. Poser, C.M., Zosa, A.M., Gomez, A.J., et al.: Cervicocephalic angiography for cerebrovascular insufficiency. Acta neurol. scand. 40, 321 (1964)

    Google Scholar 

  19. Skalpe, I.O., Amundsen, P.: Lumbar radiculography with metrizamide. A nonionic water-soluble contrast medium. Radiology 115, 91 (1975)

    Google Scholar 

  20. Skalpe, I.O., Amundsen, P.: Thoracic and cervical myelography with metrizamide. Clinical experiences with a water-soluble, non-ionic contrast medium. Radiology 116, 101 (1975)

    Google Scholar 

  21. Skalpe, I.O., Evensen, A.: Cell injury and cell regeneration in selective renal arteriography in rabbits. A preliminary report. Invest. Radiol. 6, 299 (1971)

    Google Scholar 

  22. Skalpe, I.O., Evensen, A.: Toxicity of metrizamide, meglumine iocarmate and sodium metrizoate in selective nephroangiography. An experimental investigation in rabbits. Acta radiol. suppl. 335, 175 (1973)

    Google Scholar 

  23. Skalpe, I.O., Evensen, A., Strømme, J.H.: Toxicity of metrizamide and metrizoate in selective coeliac angiography. An experimental investigation in rabbits. Acta radiol. suppl. 335, 186 (1973)

    Google Scholar 

  24. Skalpe, I.O., Torvik, A.: Toxicity of metrizamide and meglumine iocarmate in the spinal subarachnoid space. An experimental study in rats with special reference to long-term effects. Invest. Radiol. 10, 154 (1975)

    Google Scholar 

  25. Talle, K., Lundervold, A.: EEG, ECG and other recordings in cerebral angiography. Acta radiol. diagn. 15, 250 (1974)

    Google Scholar 

  26. Törmä, T., Fogelholm, R.: Complications of cerebral angiography with urografin. Acta neurol. scand. 43, 616 (1967)

    Google Scholar 

  27. Wishart, D.L.: Complications in vertebral angiography as compared to non-vertebral cerebral angiography in 447 studies. Amer. J. Roentgenol. 113, 527 (1971)

    Google Scholar 

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Authors and Affiliations

  1. Neuroradiological Section of the X-ray Department, University Hospital, Oslo 1, Norway

    I. O. Skalpe

  2. Institute for Surgical Research Rikshospitalet, University Hospital, Oslo 1, Norway

    I. O. Skalpe

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  1. I. O. Skalpe
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Skalpe, I.O. The toxicity of the non-ionic watersoluble contrast medium metrizamide (Amipaque) in selective vertebral angiography. Neuroradiology 13, 19–24 (1977). https://doi.org/10.1007/BF00335030

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  • DOI: https://doi.org/10.1007/BF00335030

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