Archives of Toxicology

, Volume 42, Issue 4, pp 295–301 | Cite as

Some cases of acute intoxications from compulsive use of isoaminile

  • M. Marigo
  • S. D. Ferrara
  • L. Cima
  • P. Giusti
  • M. Floreani
Original Investigations


Isoaminile (Peracon) has found in Italy a certain success as a substitute for hard narcotics. Three observations are reported in which five young adults have been intoxicated by the i.v. administration of the cough suppressant. On the basis of two opposed points of view suggested by the Literature to explain the compulsive abuse of this drug, the A. have studied its physical dependence capacity by using an original technique. The isoaminile cyanide release has been measured too. The experimental results demonstrate that isoaminile does not determine a physical dependence; a slight CN release activity occurs in vivo only with high doses.

Key words

Isoaminile Compulsive abuse Acute intoxication Physical dependence test Cyanide release 


Isoaminil (Peracon) wurde in Italien als Drogenersatz in gewissem Umfang verwendet. Drei Beobachtungen werden berichtet. Fünf junge Leute hatten das Antitussivum in Überdosis intravenös gespritzt und zeigten schwere Symptome einer Vergiftung ähnlich wie mit Morphinderivaten. Im Tierversuch wurde festgestellt, daß Isoaminil keine Abhängigkeit erzeugte, aber Cyanid freisetzte. Allerdings waren die Mengen an Rhodanid im Urin von Ratten gering.


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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • M. Marigo
    • 1
  • S. D. Ferrara
    • 1
  • L. Cima
    • 2
  • P. Giusti
    • 2
  • M. Floreani
    • 2
  1. 1.Institute of Forensic Medicine, Padua UniversityPaduaItaly
  2. 2.Institute of Pharmacology, Padua UniversityPaduaItaly

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