Skip to main content
SpringerLink
Log in

Interactions between the yeast mitochondrial and nuclear genomes: isogenic suppressive and hypersuppressive petites differ in their resistance to the alkaloid lycorine

  • Short Communication
  • Published:
Current Genetics Aims and scope Submit manuscript

Summary

In a previous paper we have shown that the alkaloid lycorine inhibits growth of rho +, mit - and rho -, strains of Saccharomyces cerevisiae, whereas strains devoid of mitochondrial DNA (rho o) are resistant to more than 200 μg/ml of the alkaloid. In this report we show that hypersuppressive petites are almost as resistant as rho o mutants, whereas isogenic rho - petites, which have retained tained longer segments of the genome, are sensitive to the drug.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Arrigoni O, Arrigoni-Liso R, Calabrese G (1975) Nature 256:513–514

    Google Scholar 

  • Barath Z, Küntzel H (1972) Proc Natl Acad Sci USA 69:1371–1374

    Google Scholar 

  • Blanc H (1984) Gene 30:47–61

    Google Scholar 

  • Blanc H, Dujon B (1980) Proc Natl Acad Sci USA 77:3942–3946

    Google Scholar 

  • Butow RA, Docherty R, Parikh VS (1988) Phil Trans R Soc London 319:127–133

    Google Scholar 

  • DelGiudice L, Massardo DR, Manna F Evidente A, Randazzo G, Wolf K (1984) Curr Genet 8:493–498 (Erratum: Curr Genet 9:183(1985))

    Google Scholar 

  • Dujon B (1981) In: Strathern JN, Hones EN, Broach JR (eds) Molecular biology of the yeast Saccharomyces: life cycle and inheritance. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp 505–635

    Google Scholar 

  • Haußmann P, Zimmermann FK (1976) Mol Gen Genet 148:205–211

    Google Scholar 

  • Parikh VS, Morgan MM, Scott R, Clements LS, Butow RA (1987) Science 235:576–580

    Google Scholar 

  • Parikh VS, Conrad-Webb H, Docherty R, Butow RA (1989) Mol Cell Biol 9:1897–1907

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Istituto Internazionale di Genetica e Biofisica, Via G. Marconi 10, I-80125, Napoli, Italy

    Domenica Rita Massardo, Filomena Manna & Luigi Del Giudice

  2. Institut für Mikrobiologie und Weinforschung der Johannes Gutenberg-Universität, Becherweg 15, D-6500, Mainz, Federal Republic of Germany

    Klaus Wolf

Authors
  1. Domenica Rita Massardo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Filomena Manna
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Luigi Del Giudice
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Klaus Wolf
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Massardo, D.R., Manna, F., Del Giudice, L. et al. Interactions between the yeast mitochondrial and nuclear genomes: isogenic suppressive and hypersuppressive petites differ in their resistance to the alkaloid lycorine. Curr Genet 17, 455–457 (1990). https://doi.org/10.1007/BF00334527

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00334527

Key words

Search

Navigation