Summary
Studies of complementation patterns of ura2 mutants of the pyrimidine pathway in Saccharomyces cerevisiae suggest the existence of at least two different structural genes in the ura2 locus: one coding for carbamyl phosphate synthetase, ura2C and the other coding for aspartic transcarbamylase, ura2A. An interallelic type of complementation takes place among some ura2A mutants, but was not noted among the ura2C class (Fig. 2). Preliminary results of the mapping of suppressible mutants indicate that the complex is transcribed into a single messenger RNA, with the direction of transcription proceeding from the CPSase region to the ATCase region.
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Denis-Duphil, M., Lacroute, F. Fine structure of the ura 2 locus in Saccharomyces cerevisiae . Molec. Gen. Genetics 112, 354–364 (1971). https://doi.org/10.1007/BF00334436
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DOI: https://doi.org/10.1007/BF00334436