Abstract
Seventy-two eugonadal women, mean age 39±4 years, with a z score for total body bone mineral content (BMC) of less than -1.5 (mean -1.80±0.12) were selected from a previous screening study of normal values of total body and regional BMC in women using dual-energy X-ray absorptiometry. The women were distributed into two groups: 36 women undergoing treatment with 1 g/day of elemental calcium in the form of calcium pidolate and 36 women not treated. One year later, total body BMC, regional BMC in arms, legs and trunk, 24-hour urinary calicum excretion (Ca 24 hour), fasting urinary calcium/creatinine ratio, and serum tartrate-resistant acid phosphatase concentration were measured in both groups. There was a significant increase in total body and regional BMC (P<0.001) in the group taking calcium pidolate. The increase was greater in arms and legs (2.5%) than in trunk (1.7%), being 2.6% for total body BMC. The z score increased from -1.81±0.13 to -1.52±0.12 (16%, P<0.001). The corporal index did not change, and total body BMC corrected for fat-free body mass increased by 6.7% (P<0.001). These changes were accompanied by an increase in 24-hour urinary calcium excretion and a decrease in urinary calcium/creatinine ratio and serum tartrate-resistant acid phosphatase concentration (P<0.05 for all). There was a correlation between cumulative calcium dose at the end of treatment and gain in total body BMC (r2=0.925, P<0.001). The untreated group showed no changes. These results indicate that administration of 1 g/day of elemental calcium in the form of calcium pidolate to eugonadal women increases total and regional bone mass.
Similar content being viewed by others
References
Cumming RG (1990) Calcium intake and bone mass: a quantitative review of the evidence. Calcif Tissue Int 47: 194–201
Matkovic V (1991) Calcium metabolism and calcium requirements during skeletal modeling and consolidation of bone mass. Am J Clin Nutr 54 (suppl 1): 245S-260S
Ekman M, Reinzenstein P, Teigen SW, Ronnerberg R (1991) Comparative absorption of calcium from carbonate tablets, lactogluconate/carbonate effervescent tablet, and chloride solution. Bone 12: 93–97
Dawson-Hughes B, Dallal GE, Krall EA, Sadowski L, Sahyoun N, Tannenbaum S (1990) A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. N Engl J Med 323: 878–883
Rico H, Revilla M, Hernandez ER, Villa LF, Alvarez de Buergo Ma (1992) Total and regional bone mineral content in relation to menopause. Maturitas 15: 233–240
Sartoris DJ, Resnick D (1990) Current and innovate methods for noninvasive bone densitometry. Radiol Clin North Am 28: 257–278
Marchandise X, Pagniez D, Ythier H, Gilquin B, Duquesnoy B, Wemeau JL (1987) Influence of accompanying anion on intestinal radiocalcium absorption. Calcif Tissue Int 40: 8–11
Rico H, Revilla M, Hernandez ER, Villa LF, López-Alonso A (1991) Total and regional bone mineral content in normal premenopausal women. Clin Rheumatol 10: 423–425
Rico H, Cabranes JA, Hernandez ER, Perez del Molino J, Escudero G (1990) Effect of calcium pidolate on biochemical and hormonal parameters in involutional osteoporosis. Maturitas 12: 105–111
Wolman RL, Clark P, McNally E, Harries MG, Reeve J (1992) Dietary calcium as a statistical determinant of spinal trabecular bone density in amenorrhoeic and oestrogen-replete athletes. Bone Miner 17: 415–423
Johnston CC, Miller JZ, Slemenda CW, Reister TK, Hui S, Christian JC, Peacock M (1992) Calcium supplementation and increases in bone mineral density in children. N Engl J Med 327: 82–87
Pak CYC (1991) Calcium citrate for the prevention of postmenopausal osteoporosis. Pharmacol Treat Endocrinol 5: 76–95
Sentipal JM, Wardlaw GM, Mahan J, Matkovic V (1991) Influence of calcium intake and growth indexes on vertebral bone mineral density in young females. Am J Clin Nutr 54(2): 425–428
Chan GM (1991) Dietary calcium and bone mineral status of children and adolescents. Am J Dis Child 145: 631–634
Elders PJM, Netelenbos JC, Lips P, van Ginkel FC, Khoe E, Leeuwenkamp OR, Hackeng WHL, van der Stelt P (1991) Calcium supplementation reduces vertebral bone loss in perimenopausal women: a controlled trial in 248 women between 46 and 55 years of age. J Clin Endocrinol Metab 73: 533–540
Baran D, Sorensen A, Grimes J, Lew R, Karellas A, Johnson B, Roche J (1990) Dietary modification with dairy products for preventing vertebral bone loss in premenopausal women: a three-year prospective study. J Clin Endocrinol Metab 70: 264–270
Elders PJM (1991) Perimenopausal bone loss. VU University Press, Amsterdam
Riis B, Thomsen K, N Christiansen C (1987) Does calcium supplementation prevent postmenopausal bone loss? N Engl J Med 316: 173–177
Ettinger B, Gennat MK, Cann ChE (1987) Postmenopausal bone loss is prevented by treatment with low-dosage estrogen with calcium. Ann Intern Med 106: 40–45
Geusens P, Schot LPC, Nijs J, Dequeker J (1991) Calcium-deficient diet in ovariectomized dogs limits the effects of 17β-estradiol and nondrolone decaonate on bone. J Bone Miner Res 6: 791–797
Picard D, Ste-Marie LG, Carrier L, Chartrand R, Lepage R, D'Amour P (1987) Influence of calcium intake during early adulthood on bone mineral content in premenopausal women. In: Cohn DV, Martin TJ, Meunier PJ (eds) Calcium regulation and bone metabolism. Basic and clinical aspects, vol.9 Elsevier Science Publishers, Amsterdam, pp 128–132
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rico, H., Revilla, M., Villa, L.F. et al. Longitudinal study of the effect of calcium pidolate on bone mass in eugonadal women. Calcif Tissue Int 54, 477–480 (1994). https://doi.org/10.1007/BF00334327
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00334327