Summary
In a diploid strain heteroallelic at the ade3 locus, the mitotic intragenic recombination frequency is enhanced ten fold when the cell population is starved for histidine (Hénaut et Luzzati, 1971). By studying simultaneous recombinational events at two independant loci, it is shown that the effect of histidine starvation is most simply explained in term of an increase in the frequency of cells capable of recombination. In these competent cells, intragenic recombination frequencies during mitosis are equal to those found during meiosis. However, the frequency of recombination between the gene and the centromere appears to be lower during mitosis than during meiosis.
We believe that histidine starvation in ade3 strains stimulates chromosome pairing, and that there is no fundamental difference between mitotic and meiotic recombination.
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Mémoire présenté par G. Magni
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Hénaut, A., Luzzati, M. Contrôle de l'aptitude à recombiner pendant la phase végétative chez Saccharomyces cerevisiae . Molec. gen. Genet. 116, 26–34 (1972). https://doi.org/10.1007/BF00334256
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DOI: https://doi.org/10.1007/BF00334256