Summary
Rough R strains of Haemophilus influenzae derived from the smooth (S) serotypes Sa, Sb, Sd, Se and Sf each carry DNA restriction and modification systems. The DNA host specificity determined by Re and Rf may be the same but is different from that for Ra, Rb and Rd all of which can be distinguished from one another.
Strain Ra carries two genetically distinct host specificity systems A1 and A2 each of which is able to restrict Haemophilus phage HP1, and each of which confers a specific modification on phage grown in strain Ra. Among restriction-deficient mutants isolated from strain Ra, seven of the eight possible phenotypes for these two systems were obtained after either one or two mutational steps.
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Piekarowicz, A., Glover, S.W. Host specificity of DNA in Haemophilus influenzae: The two restriction and modification systems in strain Ra . Molec. gen. Genet. 116, 11–25 (1972). https://doi.org/10.1007/BF00334255
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DOI: https://doi.org/10.1007/BF00334255