Summary
Chloramphenicol (CLP) at slightly inhibitory concentrations (3–5 μg/ml) suppresses the inhibition of DNA synthesis and cell division caused by the temperature sensitive mutation dnaE486 at the nonpermissive temperature. Some other mutations can also be phenotypically suppressed by CLP. A similar effect is shown by chlortetracycline. Phenotypic suppression is caused by both these drugs in different cases than by streptomycin.
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Communicated by B.A. Bridges
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Kuhrová, V., Koukalová, B. & Reich, J. Ability of chloramphenicol to suppress phenotypically some bacterial mutations. Molec. Gen. Genet. 160, 319–324 (1978). https://doi.org/10.1007/BF00332975
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DOI: https://doi.org/10.1007/BF00332975